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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7WLD

Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 Angstrom resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(G)		Glycosylphosphatidylinositol anchor attachment 1 proteinpolymer88696990.41UniProt (O43292)
Pfam (PF04114)		Homo sapiens (human)GPI anchor attachment protein 1,GAA1 protein homolog,hGAA1
2B
(K)		GPI-anchor transamidasepolymer64773443.11UniProt (Q92643)
Pfam (PF01650)		Homo sapiens (human)GPI transamidase,GPI8 homolog,hGPI8,Phosphatidylinositol-glycan biosynthesis class K protein,PIG-K
3C
(S)		GPI transamidase component PIG-Spolymer81690421.11UniProt (Q96S52)
Pfam (PF10510)		Homo sapiens (human)Phosphatidylinositol-glycan biosynthesis class S protein
4D
(T)		GPI transamidase component PIG-Tpolymer83194207.31UniProt (Q969N2)
Pfam (PF04113)		Homo sapiens (human)Phosphatidylinositol-glycan biosynthesis class T protein
5E
(U)		Phosphatidylinositol glycan anchor biosynthesis class U proteinpolymer71280691.51UniProt (Q9H490)
Pfam (PF06728)		Homo sapiens (human)Cell division cycle protein 91-like 1,Protein CDC91-like 1,GPI transamidase component PIG-U
6F
(A)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
7DA, EA, FA, G, H...
(U, G)		CHOLESTEROL HEMISUCCINATEnon-polymer486.79Chemie (Y01)
PubChem (16219150)
PubChem (22210610)
PubChem (65082)
PubChem (363416)
PubChem (45489984)
PubChem (500055)
PubChem (60078761)
PubChem (57163942)
PubChem (73440805)
PubChem (89891013)
PubChem (13301926)
PubChem (13301927)
PubChem (99567469)
PubChem (99567468)
PubChem (124427194)
PubChem (124897021)
PubChem (124897020)
PubChem (10005657)
PubChem (130340716)
PubChem (11969853)
PubChem (124301053)
PubChem (124302591)
PubChem (124303794)
PubChem (124421343)
PubChem (124427195)
PubChem (137392566)
PubChem (137496323)
PubChem (124914595)
PubChem (124914596)
PubChem (131705526)
PubChem (155804219)
PubChem (137332121)
PubChem (137496357)
PubChem (146157332)
PubChem (169132514)
PubChem (154929912)
PubChem (155199678)
PubChem (156327905)
PubChem (156426247)
PubChem (156516588)
PubChem (166979870)
PubChem (167024614)
PubChem (169132513)
PubChem (170117245)
PubChem (172400028)
8I
(G)		Digitoninnon-polymer1229.31Chemie (AJP)
9J, K
(G)		(4S,7R)-7-[(hexadecanoyloxy)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5,8-trioxa-4lambda~5~-phosphahexacosan-1-aminiumnon-polymer763.12Chemie (BJR)
10L
(G)		1,2-dioleoyl-sn-glycero-3-phosphoethanolaminenon-polymer744.01Chemie (PEE)
PubChem (108229)
PubChem (44891344)
PubChem (54095275)
PubChem (14238554)
PubChem (6437392)
PubChem (9546744)
PubChem (99655478)
PubChem (99655479)
PubChem (5909904)
PubChem (9546757)
PubChem (138113035)
PubChem (171729549)
11P
(K)		CALCIUM IONnon-polymer40.11Chemie (CA)
PubChem (271)
12Q
(K)		O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serinenon-polymer792.11Chemie (P5S)
PubChem (9547075)
PubChem (10417847)
PubChem (9547096)
PubChem (125040277)
PubChem (15409341)
PubChem (133612130)
PubChem (165429904)
13R, W
(S, T)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
14AA, BA, S, T, U
(U, S)		CHOLESTEROLnon-polymer386.75Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (18640088)
PubChem (1715243)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (1715244)
PubChem (23423981)
PubChem (45044259)
PubChem (638019)
PubChem (49853509)
PubChem (50990013)
PubChem (44654663)
PubChem (52934537)
PubChem (56621683)
PubChem (1549081)
PubChem (1553803)
PubChem (46937002)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (59274407)
PubChem (5283629)
PubChem (5284644)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (5315842)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (6419195)
PubChem (5997)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (1551269)
PubChem (90070115)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (117965027)
PubChem (6432564)
PubChem (101624109)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (138967089)
PubChem (139566851)
PubChem (130459183)
PubChem (131992107)
PubChem (15939944)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (171828367)
PubChem (173516975)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
15V
(T)		2-azanylethyl [(2~{S},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphatenon-polymer303.21Chemie (05E)
PubChem (163196951)
16X
(T)		2-amino-2-deoxy-alpha-D-glucopyranosenon-polymer179.21Chemie (PA1)
17Y
(U)		CARDIOLIPINnon-polymer1464.01Chemie (CDL)
PubChem (17753886)
PubChem (5287898)
18CA
(U)		[(2R)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoatenon-polymer720.01Chemie (DKB)
19GA
(U)		[(2~{R})-1-hexadecanoyloxy-3-[[(1~{S},2~{R},3~{R},4~{S},5~{S},6~{R})-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-propan-2-yl] (9~{Z},11~{Z})-octadeca-9,11-dienoatenon-polymer1073.51Chemie (06O)
PubChem (163321739)
Sequence modifications
G: 2 - 621 (UniProt: O43292)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Gly 0-expression tag
Ser 1-expression tag
Gly 622-expression tag
Thr 623-expression tag
Leu 624-expression tag
Glu 625-expression tag
Val 626-expression tag
Leu 627-expression tag
Phe 628-expression tag
Gln 629-expression tag
Gly 630-expression tag
Pro 631-expression tag
Gly 632-expression tag
Gly 633-expression tag
Ser 634-expression tag
Gly 635-expression tag
Gly 636-expression tag
Ser 637-expression tag
Ala 638-expression tag
Ser 639-expression tag
Val 640-expression tag
Ile 641-expression tag
Lys 642-expression tag
Pro 643-expression tag
Glu 644-expression tag
Met 645-expression tag
Lys 646-expression tag
Ile 647-expression tag
Lys 648-expression tag
Leu 649-expression tag
Arg 650-expression tag
Met 651-expression tag
Glu 652-expression tag
Gly 653-expression tag
Ala 654-expression tag
Val 655-expression tag
Asn 656-expression tag
Gly 657-expression tag
His 658-expression tag
Lys 659-expression tag
Phe 660-expression tag
Val 661-expression tag
Ile 662-expression tag
Glu 663-expression tag
Gly 664-expression tag
Glu 665-expression tag
Gly 666-expression tag
Ile 667-expression tag
Gly 668-expression tag
Lys 669-expression tag
Pro 670-expression tag
Tyr 671-expression tag
Glu 672-expression tag
Gly 673-expression tag
Thr 674-expression tag
Gln 675-expression tag
Thr 676-expression tag
Leu 677-expression tag
Asp 678-expression tag
Leu 679-expression tag
Thr 680-expression tag
Val 681-expression tag
Glu 682-expression tag
Glu 683-expression tag
Gly 684-expression tag
Ala 685-expression tag
Pro 686-expression tag
Leu 687-expression tag
Pro 688-expression tag
Phe 689-expression tag
Ser 690-expression tag
Tyr 691-expression tag
Asp 692-expression tag
Ile 693-expression tag
Leu 694-expression tag
Thr 695-expression tag
Pro 696-expression tag
Ala 697-expression tag
Phe 698-expression tag
Gln 699-expression tag
Tyr 700-expression tag
Gly 701-expression tag
Asn 702-expression tag
Arg 703-expression tag
Ala 704-expression tag
Phe 705-expression tag
Thr 706-expression tag
Lys 707-expression tag
Tyr 708-expression tag
Pro 709-expression tag
Glu 710-expression tag
Asp 711-expression tag
Ile 712-expression tag
Pro 713-expression tag
Asp 714-expression tag
Tyr 715-expression tag
Phe 716-expression tag
Lys 717-expression tag
Gln 718-expression tag
Ala 719-expression tag
Phe 720-expression tag
Pro 721-expression tag
Glu 722-expression tag
Gly 723-expression tag
Tyr 724-expression tag
Ser 725-expression tag
Trp 726-expression tag
Glu 727-expression tag
Arg 728-expression tag
Ser 729-expression tag
Met 730-expression tag
Thr 731-expression tag
Tyr 732-expression tag
Glu 733-expression tag
Asp 734-expression tag
Gln 735-expression tag
Gly 736-expression tag
Ile 737-expression tag
Cys 738-expression tag
Ile 739-expression tag
Ala 740-expression tag
Thr 741-expression tag
Ser 742-expression tag
Asp 743-expression tag
Ile 744-expression tag
Thr 745-expression tag
Met 746-expression tag
Glu 747-expression tag
Gly 748-expression tag
Asp 749-expression tag
Cys 750-expression tag
Phe 751-expression tag
Phe 752-expression tag
Tyr 753-expression tag
Glu 754-expression tag
Ile 755-expression tag
Arg 756-expression tag
Phe 757-expression tag
Asp 758-expression tag
Gly 759-expression tag
Thr 760-expression tag
Asn 761-expression tag
Phe 762-expression tag
Pro 763-expression tag
Pro 764-expression tag
Asn 765-expression tag
Gly 766-expression tag
Pro 767-expression tag
Val 768-expression tag
Met 769-expression tag
Gln 770-expression tag
Lys 771-expression tag
Lys 772-expression tag
Thr 773-expression tag
Leu 774-expression tag
Lys 775-expression tag
Trp 776-expression tag
Glu 777-expression tag
Pro 778-expression tag
Ser 779-expression tag
Thr 780-expression tag
Glu 781-expression tag
Lys 782-expression tag
Met 783-expression tag
Tyr 784-expression tag
Val 785-expression tag
Glu 786-expression tag
Asp 787-expression tag
Gly 788-expression tag
Val 789-expression tag
Leu 790-expression tag
Lys 791-expression tag
Gly 792-expression tag
Asp 793-expression tag
Val 794-expression tag
Glu 795-expression tag
Met 796-expression tag
Ala 797-expression tag
Leu 798-expression tag
Leu 799-expression tag
Leu 800-expression tag
Glu 801-expression tag
Gly 802-expression tag
Gly 803-expression tag
Gly 804-expression tag
His 805-expression tag
Tyr 806-expression tag
Arg 807-expression tag
Cys 808-expression tag
Asp 809-expression tag
Phe 810-expression tag
Lys 811-expression tag
Thr 812-expression tag
Thr 813-expression tag
Tyr 814-expression tag
Lys 815-expression tag
Ala 816-expression tag
Lys 817-expression tag
Lys 818-expression tag
Asp 819-expression tag
Val 820-expression tag
Arg 821-expression tag
Leu 822-expression tag
Pro 823-expression tag
Asp 824-expression tag
Ala 825-expression tag
His 826-expression tag
Glu 827-expression tag
Val 828-expression tag
Asp 829-expression tag
His 830-expression tag
Arg 831-expression tag
Ile 832-expression tag
Glu 833-expression tag
Ile 834-expression tag
Leu 835-expression tag
Ser 836-expression tag
His 837-expression tag
Asp 838-expression tag
Lys 839-expression tag
Asp 840-expression tag
Tyr 841-expression tag
Asn 842-expression tag
Lys 843-expression tag
Val 844-expression tag
Arg 845-expression tag
Leu 846-expression tag
Tyr 847-expression tag
Glu 848-expression tag
His 849-expression tag
Ala 850-expression tag
Glu 851-expression tag
Ala 852-expression tag
Arg 853-expression tag
Tyr 854-expression tag
Ser 855-expression tag
Gly 856-expression tag
Gly 857-expression tag
Gly 858-expression tag
Ser 859-expression tag
Gly 860-expression tag
Gly 861-expression tag
Gly 862-expression tag
Gly 863-expression tag
Ser 864-expression tag
Gly 865-expression tag
Gly 866-expression tag
Gly 867-expression tag
Gly 868-expression tag
Asp 869-expression tag
Tyr 870-expression tag
Lys 871-expression tag
Asp 872-expression tag
Asp 873-expression tag
Asp 874-expression tag
Asp 875-expression tag
Ala 876-expression tag
Asp 877-expression tag
Tyr 878-expression tag
Lys 879-expression tag
Asp 880-expression tag
Asp 881-expression tag
Asp 882-expression tag
Asp 883-expression tag
Ala 884-expression tag
K: 2 - 395 (UniProt: Q92643)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Gly 0-expression tag
Ser 1-expression tag
Gly 396-expression tag
Thr 397-expression tag
Leu 398-expression tag
Glu 399-expression tag
Val 400-expression tag
Leu 401-expression tag
Phe 402-expression tag
Gln 403-expression tag
Gly 404-expression tag
Pro 405-expression tag
Gly 406-expression tag
Gly 407-expression tag
Ser 408-expression tag
Gly 409-expression tag
Gly 410-expression tag
Ser 411-expression tag
Ala 412-expression tag
Ser 413-expression tag
Val 414-expression tag
Ile 415-expression tag
Lys 416-expression tag
Pro 417-expression tag
Glu 418-expression tag
Met 419-expression tag
Lys 420-expression tag
Ile 421-expression tag
Lys 422-expression tag
Leu 423-expression tag
Arg 424-expression tag
Met 425-expression tag
Glu 426-expression tag
Gly 427-expression tag
Ala 428-expression tag
Val 429-expression tag
Asn 430-expression tag
Gly 431-expression tag
His 432-expression tag
Lys 433-expression tag
Phe 434-expression tag
Val 435-expression tag
Ile 436-expression tag
Glu 437-expression tag
Gly 438-expression tag
Glu 439-expression tag
Gly 440-expression tag
Ile 441-expression tag
Gly 442-expression tag
Lys 443-expression tag
Pro 444-expression tag
Tyr 445-expression tag
Glu 446-expression tag
Gly 447-expression tag
Thr 448-expression tag
Gln 449-expression tag
Thr 450-expression tag
Leu 451-expression tag
Asp 452-expression tag
Leu 453-expression tag
Thr 454-expression tag
Val 455-expression tag
Glu 456-expression tag
Glu 457-expression tag
Gly 458-expression tag
Ala 459-expression tag
Pro 460-expression tag
Leu 461-expression tag
Pro 462-expression tag
Phe 463-expression tag
Ser 464-expression tag
Tyr 465-expression tag
Asp 466-expression tag
Ile 467-expression tag
Leu 468-expression tag
Thr 469-expression tag
Pro 470-expression tag
Ala 471-expression tag
Phe 472-expression tag
Gln 473-expression tag
Tyr 474-expression tag
Gly 475-expression tag
Asn 476-expression tag
Arg 477-expression tag
Ala 478-expression tag
Phe 479-expression tag
Thr 480-expression tag
Lys 481-expression tag
Tyr 482-expression tag
Pro 483-expression tag
Glu 484-expression tag
Asp 485-expression tag
Ile 486-expression tag
Pro 487-expression tag
Asp 488-expression tag
Tyr 489-expression tag
Phe 490-expression tag
Lys 491-expression tag
Gln 492-expression tag
Ala 493-expression tag
Phe 494-expression tag
Pro 495-expression tag
Glu 496-expression tag
Gly 497-expression tag
Tyr 498-expression tag
Ser 499-expression tag
Trp 500-expression tag
Glu 501-expression tag
Arg 502-expression tag
Ser 503-expression tag
Met 504-expression tag
Thr 505-expression tag
Tyr 506-expression tag
Glu 507-expression tag
Asp 508-expression tag
Gln 509-expression tag
Gly 510-expression tag
Ile 511-expression tag
Cys 512-expression tag
Ile 513-expression tag
Ala 514-expression tag
Thr 515-expression tag
Ser 516-expression tag
Asp 517-expression tag
Ile 518-expression tag
Thr 519-expression tag
Met 520-expression tag
Glu 521-expression tag
Gly 522-expression tag
Asp 523-expression tag
Cys 524-expression tag
Phe 525-expression tag
Phe 526-expression tag
Tyr 527-expression tag
Glu 528-expression tag
Ile 529-expression tag
Arg 530-expression tag
Phe 531-expression tag
Asp 532-expression tag
Gly 533-expression tag
Thr 534-expression tag
Asn 535-expression tag
Phe 536-expression tag
Pro 537-expression tag
Pro 538-expression tag
Asn 539-expression tag
Gly 540-expression tag
Pro 541-expression tag
Val 542-expression tag
Met 543-expression tag
Gln 544-expression tag
Lys 545-expression tag
Lys 546-expression tag
Thr 547-expression tag
Leu 548-expression tag
Lys 549-expression tag
Trp 550-expression tag
Glu 551-expression tag
Pro 552-expression tag
Ser 553-expression tag
Thr 554-expression tag
Glu 555-expression tag
Lys 556-expression tag
Met 557-expression tag
Tyr 558-expression tag
Val 559-expression tag
Glu 560-expression tag
Asp 561-expression tag
Gly 562-expression tag
Val 563-expression tag
Leu 564-expression tag
Lys 565-expression tag
Gly 566-expression tag
Asp 567-expression tag
Val 568-expression tag
Glu 569-expression tag
Met 570-expression tag
Ala 571-expression tag
Leu 572-expression tag
Leu 573-expression tag
Leu 574-expression tag
Glu 575-expression tag
Gly 576-expression tag
Gly 577-expression tag
Gly 578-expression tag
His 579-expression tag
Tyr 580-expression tag
Arg 581-expression tag
Cys 582-expression tag
Asp 583-expression tag
Phe 584-expression tag
Lys 585-expression tag
Thr 586-expression tag
Thr 587-expression tag
Tyr 588-expression tag
Lys 589-expression tag
Ala 590-expression tag
Lys 591-expression tag
Lys 592-expression tag
Asp 593-expression tag
Val 594-expression tag
Arg 595-expression tag
Leu 596-expression tag
Pro 597-expression tag
Asp 598-expression tag
Ala 599-expression tag
His 600-expression tag
Glu 601-expression tag
Val 602-expression tag
Asp 603-expression tag
His 604-expression tag
Arg 605-expression tag
Ile 606-expression tag
Glu 607-expression tag
Ile 608-expression tag
Leu 609-expression tag
Ser 610-expression tag
His 611-expression tag
Asp 612-expression tag
Lys 613-expression tag
Asp 614-expression tag
Tyr 615-expression tag
Asn 616-expression tag
Lys 617-expression tag
Val 618-expression tag
Arg 619-expression tag
Leu 620-expression tag
Tyr 621-expression tag
Glu 622-expression tag
His 623-expression tag
Ala 624-expression tag
Glu 625-expression tag
Ala 626-expression tag
Arg 627-expression tag
Tyr 628-expression tag
Ser 629-expression tag
Gly 630-expression tag
Gly 631-expression tag
Gly 632-expression tag
Ser 633-expression tag
Gly 634-expression tag
Gly 635-expression tag
Gly 636-expression tag
Tyr 637-expression tag
Pro 638-expression tag
Tyr 639-expression tag
Asp 640-expression tag
Val 641-expression tag
Pro 642-expression tag
Asp 643-expression tag
Tyr 644-expression tag
Ala 645-expression tag
S: 2 - 555 (UniProt: Q96S52)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Gly 0-expression tag
Ser 1-expression tag
Gly 556-expression tag
Thr 557-expression tag
Leu 558-expression tag
Glu 559-expression tag
Val 560-expression tag
Leu 561-expression tag
Phe 562-expression tag
Gln 563-expression tag
Gly 564-expression tag
Pro 565-expression tag
Gly 566-expression tag
Gly 567-expression tag
Ser 568-expression tag
Gly 569-expression tag
Gly 570-expression tag
Ser 571-expression tag
Ala 572-expression tag
Ser 573-expression tag
Val 574-expression tag
Ile 575-expression tag
Lys 576-expression tag
Pro 577-expression tag
Glu 578-expression tag
Met 579-expression tag
Lys 580-expression tag
Ile 581-expression tag
Lys 582-expression tag
Leu 583-expression tag
Arg 584-expression tag
Met 585-expression tag
Glu 586-expression tag
Gly 587-expression tag
Ala 588-expression tag
Val 589-expression tag
Asn 590-expression tag
Gly 591-expression tag
His 592-expression tag
Lys 593-expression tag
Phe 594-expression tag
Val 595-expression tag
Ile 596-expression tag
Glu 597-expression tag
Gly 598-expression tag
Glu 599-expression tag
Gly 600-expression tag
Ile 601-expression tag
Gly 602-expression tag
Lys 603-expression tag
Pro 604-expression tag
Tyr 605-expression tag
Glu 606-expression tag
Gly 607-expression tag
Thr 608-expression tag
Gln 609-expression tag
Thr 610-expression tag
Leu 611-expression tag
Asp 612-expression tag
Leu 613-expression tag
Thr 614-expression tag
Val 615-expression tag
Glu 616-expression tag
Glu 617-expression tag
Gly 618-expression tag
Ala 619-expression tag
Pro 620-expression tag
Leu 621-expression tag
Pro 622-expression tag
Phe 623-expression tag
Ser 624-expression tag
Tyr 625-expression tag
Asp 626-expression tag
Ile 627-expression tag
Leu 628-expression tag
Thr 629-expression tag
Pro 630-expression tag
Ala 631-expression tag
Phe 632-expression tag
Gln 633-expression tag
Tyr 634-expression tag
Gly 635-expression tag
Asn 636-expression tag
Arg 637-expression tag
Ala 638-expression tag
Phe 639-expression tag
Thr 640-expression tag
Lys 641-expression tag
Tyr 642-expression tag
Pro 643-expression tag
Glu 644-expression tag
Asp 645-expression tag
Ile 646-expression tag
Pro 647-expression tag
Asp 648-expression tag
Tyr 649-expression tag
Phe 650-expression tag
Lys 651-expression tag
Gln 652-expression tag
Ala 653-expression tag
Phe 654-expression tag
Pro 655-expression tag
Glu 656-expression tag
Gly 657-expression tag
Tyr 658-expression tag
Ser 659-expression tag
Trp 660-expression tag
Glu 661-expression tag
Arg 662-expression tag
Ser 663-expression tag
Met 664-expression tag
Thr 665-expression tag
Tyr 666-expression tag
Glu 667-expression tag
Asp 668-expression tag
Gln 669-expression tag
Gly 670-expression tag
Ile 671-expression tag
Cys 672-expression tag
Ile 673-expression tag
Ala 674-expression tag
Thr 675-expression tag
Ser 676-expression tag
Asp 677-expression tag
Ile 678-expression tag
Thr 679-expression tag
Met 680-expression tag
Glu 681-expression tag
Gly 682-expression tag
Asp 683-expression tag
Cys 684-expression tag
Phe 685-expression tag
Phe 686-expression tag
Tyr 687-expression tag
Glu 688-expression tag
Ile 689-expression tag
Arg 690-expression tag
Phe 691-expression tag
Asp 692-expression tag
Gly 693-expression tag
Thr 694-expression tag
Asn 695-expression tag
Phe 696-expression tag
Pro 697-expression tag
Pro 698-expression tag
Asn 699-expression tag
Gly 700-expression tag
Pro 701-expression tag
Val 702-expression tag
Met 703-expression tag
Gln 704-expression tag
Lys 705-expression tag
Lys 706-expression tag
Thr 707-expression tag
Leu 708-expression tag
Lys 709-expression tag
Trp 710-expression tag
Glu 711-expression tag
Pro 712-expression tag
Ser 713-expression tag
Thr 714-expression tag
Glu 715-expression tag
Lys 716-expression tag
Met 717-expression tag
Tyr 718-expression tag
Val 719-expression tag
Glu 720-expression tag
Asp 721-expression tag
Gly 722-expression tag
Val 723-expression tag
Leu 724-expression tag
Lys 725-expression tag
Gly 726-expression tag
Asp 727-expression tag
Val 728-expression tag
Glu 729-expression tag
Met 730-expression tag
Ala 731-expression tag
Leu 732-expression tag
Leu 733-expression tag
Leu 734-expression tag
Glu 735-expression tag
Gly 736-expression tag
Gly 737-expression tag
Gly 738-expression tag
His 739-expression tag
Tyr 740-expression tag
Arg 741-expression tag
Cys 742-expression tag
Asp 743-expression tag
Phe 744-expression tag
Lys 745-expression tag
Thr 746-expression tag
Thr 747-expression tag
Tyr 748-expression tag
Lys 749-expression tag
Ala 750-expression tag
Lys 751-expression tag
Lys 752-expression tag
Asp 753-expression tag
Val 754-expression tag
Arg 755-expression tag
Leu 756-expression tag
Pro 757-expression tag
Asp 758-expression tag
Ala 759-expression tag
His 760-expression tag
Glu 761-expression tag
Val 762-expression tag
Asp 763-expression tag
His 764-expression tag
Arg 765-expression tag
Ile 766-expression tag
Glu 767-expression tag
Ile 768-expression tag
Leu 769-expression tag
Ser 770-expression tag
His 771-expression tag
Asp 772-expression tag
Lys 773-expression tag
Asp 774-expression tag
Tyr 775-expression tag
Asn 776-expression tag
Lys 777-expression tag
Val 778-expression tag
Arg 779-expression tag
Leu 780-expression tag
Tyr 781-expression tag
Glu 782-expression tag
His 783-expression tag
Ala 784-expression tag
Glu 785-expression tag
Ala 786-expression tag
Arg 787-expression tag
Tyr 788-expression tag
Ser 789-expression tag
Gly 790-expression tag
Gly 791-expression tag
Gly 792-expression tag
Ser 793-expression tag
Gly 794-expression tag
Gly 795-expression tag
Gly 796-expression tag
Gly 797-expression tag
Gly 798-expression tag
Gly 799-expression tag
Gly 800-expression tag
Gly 801-expression tag
Gly 802-expression tag
Gly 803-expression tag
Gly 804-expression tag
Glu 805-expression tag
Gln 806-expression tag
Lys 807-expression tag
Leu 808-expression tag
Ile 809-expression tag
Ser 810-expression tag
Glu 811-expression tag
Glu 812-expression tag
Asp 813-expression tag
Leu 814-expression tag
T: 2 - 578 (UniProt: Q969N2)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Gly 0-expression tag
Ser 1-expression tag
Gly 579-expression tag
Thr 580-expression tag
Leu 581-expression tag
Glu 582-expression tag
Val 583-expression tag
Leu 584-expression tag
Phe 585-expression tag
Gln 586-expression tag
Gly 587-expression tag
Pro 588-expression tag
Gly 589-expression tag
Gly 590-expression tag
Ser 591-expression tag
Gly 592-expression tag
Gly 593-expression tag
Ser 594-expression tag
Ala 595-expression tag
Ser 596-expression tag
Val 597-expression tag
Ile 598-expression tag
Lys 599-expression tag
Pro 600-expression tag
Glu 601-expression tag
Met 602-expression tag
Lys 603-expression tag
Ile 604-expression tag
Lys 605-expression tag
Leu 606-expression tag
Arg 607-expression tag
Met 608-expression tag
Glu 609-expression tag
Gly 610-expression tag
Ala 611-expression tag
Val 612-expression tag
Asn 613-expression tag
Gly 614-expression tag
His 615-expression tag
Lys 616-expression tag
Phe 617-expression tag
Val 618-expression tag
Ile 619-expression tag
Glu 620-expression tag
Gly 621-expression tag
Glu 622-expression tag
Gly 623-expression tag
Ile 624-expression tag
Gly 625-expression tag
Lys 626-expression tag
Pro 627-expression tag
Tyr 628-expression tag
Glu 629-expression tag
Gly 630-expression tag
Thr 631-expression tag
Gln 632-expression tag
Thr 633-expression tag
Leu 634-expression tag
Asp 635-expression tag
Leu 636-expression tag
Thr 637-expression tag
Val 638-expression tag
Glu 639-expression tag
Glu 640-expression tag
Gly 641-expression tag
Ala 642-expression tag
Pro 643-expression tag
Leu 644-expression tag
Pro 645-expression tag
Phe 646-expression tag
Ser 647-expression tag
Tyr 648-expression tag
Asp 649-expression tag
Ile 650-expression tag
Leu 651-expression tag
Thr 652-expression tag
Pro 653-expression tag
Ala 654-expression tag
Phe 655-expression tag
Gln 656-expression tag
Tyr 657-expression tag
Gly 658-expression tag
Asn 659-expression tag
Arg 660-expression tag
Ala 661-expression tag
Phe 662-expression tag
Thr 663-expression tag
Lys 664-expression tag
Tyr 665-expression tag
Pro 666-expression tag
Glu 667-expression tag
Asp 668-expression tag
Ile 669-expression tag
Pro 670-expression tag
Asp 671-expression tag
Tyr 672-expression tag
Phe 673-expression tag
Lys 674-expression tag
Gln 675-expression tag
Ala 676-expression tag
Phe 677-expression tag
Pro 678-expression tag
Glu 679-expression tag
Gly 680-expression tag
Tyr 681-expression tag
Ser 682-expression tag
Trp 683-expression tag
Glu 684-expression tag
Arg 685-expression tag
Ser 686-expression tag
Met 687-expression tag
Thr 688-expression tag
Tyr 689-expression tag
Glu 690-expression tag
Asp 691-expression tag
Gln 692-expression tag
Gly 693-expression tag
Ile 694-expression tag
Cys 695-expression tag
Ile 696-expression tag
Ala 697-expression tag
Thr 698-expression tag
Ser 699-expression tag
Asp 700-expression tag
Ile 701-expression tag
Thr 702-expression tag
Met 703-expression tag
Glu 704-expression tag
Gly 705-expression tag
Asp 706-expression tag
Cys 707-expression tag
Phe 708-expression tag
Phe 709-expression tag
Tyr 710-expression tag
Glu 711-expression tag
Ile 712-expression tag
Arg 713-expression tag
Phe 714-expression tag
Asp 715-expression tag
Gly 716-expression tag
Thr 717-expression tag
Asn 718-expression tag
Phe 719-expression tag
Pro 720-expression tag
Pro 721-expression tag
Asn 722-expression tag
Gly 723-expression tag
Pro 724-expression tag
Val 725-expression tag
Met 726-expression tag
Gln 727-expression tag
Lys 728-expression tag
Lys 729-expression tag
Thr 730-expression tag
Leu 731-expression tag
Lys 732-expression tag
Trp 733-expression tag
Glu 734-expression tag
Pro 735-expression tag
Ser 736-expression tag
Thr 737-expression tag
Glu 738-expression tag
Lys 739-expression tag
Met 740-expression tag
Tyr 741-expression tag
Val 742-expression tag
Glu 743-expression tag
Asp 744-expression tag
Gly 745-expression tag
Val 746-expression tag
Leu 747-expression tag
Lys 748-expression tag
Gly 749-expression tag
Asp 750-expression tag
Val 751-expression tag
Glu 752-expression tag
Met 753-expression tag
Ala 754-expression tag
Leu 755-expression tag
Leu 756-expression tag
Leu 757-expression tag
Glu 758-expression tag
Gly 759-expression tag
Gly 760-expression tag
Gly 761-expression tag
His 762-expression tag
Tyr 763-expression tag
Arg 764-expression tag
Cys 765-expression tag
Asp 766-expression tag
Phe 767-expression tag
Lys 768-expression tag
Thr 769-expression tag
Thr 770-expression tag
Tyr 771-expression tag
Lys 772-expression tag
Ala 773-expression tag
Lys 774-expression tag
Lys 775-expression tag
Asp 776-expression tag
Val 777-expression tag
Arg 778-expression tag
Leu 779-expression tag
Pro 780-expression tag
Asp 781-expression tag
Ala 782-expression tag
His 783-expression tag
Glu 784-expression tag
Val 785-expression tag
Asp 786-expression tag
His 787-expression tag
Arg 788-expression tag
Ile 789-expression tag
Glu 790-expression tag
Ile 791-expression tag
Leu 792-expression tag
Ser 793-expression tag
His 794-expression tag
Asp 795-expression tag
Lys 796-expression tag
Asp 797-expression tag
Tyr 798-expression tag
Asn 799-expression tag
Lys 800-expression tag
Val 801-expression tag
Arg 802-expression tag
Leu 803-expression tag
Tyr 804-expression tag
Glu 805-expression tag
His 806-expression tag
Ala 807-expression tag
Glu 808-expression tag
Ala 809-expression tag
Arg 810-expression tag
Tyr 811-expression tag
Ser 812-expression tag
Gly 813-expression tag
Gly 814-expression tag
Gly 815-expression tag
Ser 816-expression tag
Gly 817-expression tag
Gly 818-expression tag
Gly 819-expression tag
His 820-expression tag
His 821-expression tag
His 822-expression tag
His 823-expression tag
His 824-expression tag
His 825-expression tag
His 826-expression tag
His 827-expression tag
His 828-expression tag
His 829-expression tag
U: 2 - 435 (UniProt: Q9H490)
PDBExternal DatabaseDetails
Met -1-initiating methionine
Gly 0-expression tag
Ser 1-expression tag
Gly 436-expression tag
Thr 437-expression tag
Leu 438-expression tag
Glu 439-expression tag
Val 440-expression tag
Leu 441-expression tag
Phe 442-expression tag
Gln 443-expression tag
Gly 444-expression tag
Pro 445-expression tag
Gly 446-expression tag
Gly 447-expression tag
Ser 448-expression tag
Gly 449-expression tag
Gly 450-expression tag
Ser 451-expression tag
Ala 452-expression tag
Ser 453-expression tag
Val 454-expression tag
Ile 455-expression tag
Lys 456-expression tag
Pro 457-expression tag
Glu 458-expression tag
Met 459-expression tag
Lys 460-expression tag
Ile 461-expression tag
Lys 462-expression tag
Leu 463-expression tag
Arg 464-expression tag
Met 465-expression tag
Glu 466-expression tag
Gly 467-expression tag
Ala 468-expression tag
Val 469-expression tag
Asn 470-expression tag
Gly 471-expression tag
His 472-expression tag
Lys 473-expression tag
Phe 474-expression tag
Val 475-expression tag
Ile 476-expression tag
Glu 477-expression tag
Gly 478-expression tag
Glu 479-expression tag
Gly 480-expression tag
Ile 481-expression tag
Gly 482-expression tag
Lys 483-expression tag
Pro 484-expression tag
Tyr 485-expression tag
Glu 486-expression tag
Gly 487-expression tag
Thr 488-expression tag
Gln 489-expression tag
Thr 490-expression tag
Leu 491-expression tag
Asp 492-expression tag
Leu 493-expression tag
Thr 494-expression tag
Val 495-expression tag
Glu 496-expression tag
Glu 497-expression tag
Gly 498-expression tag
Ala 499-expression tag
Pro 500-expression tag
Leu 501-expression tag
Pro 502-expression tag
Phe 503-expression tag
Ser 504-expression tag
Tyr 505-expression tag
Asp 506-expression tag
Ile 507-expression tag
Leu 508-expression tag
Thr 509-expression tag
Pro 510-expression tag
Ala 511-expression tag
Phe 512-expression tag
Gln 513-expression tag
Tyr 514-expression tag
Gly 515-expression tag
Asn 516-expression tag
Arg 517-expression tag
Ala 518-expression tag
Phe 519-expression tag
Thr 520-expression tag
Lys 521-expression tag
Tyr 522-expression tag
Pro 523-expression tag
Glu 524-expression tag
Asp 525-expression tag
Ile 526-expression tag
Pro 527-expression tag
Asp 528-expression tag
Tyr 529-expression tag
Phe 530-expression tag
Lys 531-expression tag
Gln 532-expression tag
Ala 533-expression tag
Phe 534-expression tag
Pro 535-expression tag
Glu 536-expression tag
Gly 537-expression tag
Tyr 538-expression tag
Ser 539-expression tag
Trp 540-expression tag
Glu 541-expression tag
Arg 542-expression tag
Ser 543-expression tag
Met 544-expression tag
Thr 545-expression tag
Tyr 546-expression tag
Glu 547-expression tag
Asp 548-expression tag
Gln 549-expression tag
Gly 550-expression tag
Ile 551-expression tag
Cys 552-expression tag
Ile 553-expression tag
Ala 554-expression tag
Thr 555-expression tag
Ser 556-expression tag
Asp 557-expression tag
Ile 558-expression tag
Thr 559-expression tag
Met 560-expression tag
Glu 561-expression tag
Gly 562-expression tag
Asp 563-expression tag
Cys 564-expression tag
Phe 565-expression tag
Phe 566-expression tag
Tyr 567-expression tag
Glu 568-expression tag
Ile 569-expression tag
Arg 570-expression tag
Phe 571-expression tag
Asp 572-expression tag
Gly 573-expression tag
Thr 574-expression tag
Asn 575-expression tag
Phe 576-expression tag
Pro 577-expression tag
Pro 578-expression tag
Asn 579-expression tag
Gly 580-expression tag
Pro 581-expression tag
Val 582-expression tag
Met 583-expression tag
Gln 584-expression tag
Lys 585-expression tag
Lys 586-expression tag
Thr 587-expression tag
Leu 588-expression tag
Lys 589-expression tag
Trp 590-expression tag
Glu 591-expression tag
Pro 592-expression tag
Ser 593-expression tag
Thr 594-expression tag
Glu 595-expression tag
Lys 596-expression tag
Met 597-expression tag
Tyr 598-expression tag
Val 599-expression tag
Glu 600-expression tag
Asp 601-expression tag
Gly 602-expression tag
Val 603-expression tag
Leu 604-expression tag
Lys 605-expression tag
Gly 606-expression tag
Asp 607-expression tag
Val 608-expression tag
Glu 609-expression tag
Met 610-expression tag
Ala 611-expression tag
Leu 612-expression tag
Leu 613-expression tag
Leu 614-expression tag
Glu 615-expression tag
Gly 616-expression tag
Gly 617-expression tag
Gly 618-expression tag
His 619-expression tag
Tyr 620-expression tag
Arg 621-expression tag
Cys 622-expression tag
Asp 623-expression tag
Phe 624-expression tag
Lys 625-expression tag
Thr 626-expression tag
Thr 627-expression tag
Tyr 628-expression tag
Lys 629-expression tag
Ala 630-expression tag
Lys 631-expression tag
Lys 632-expression tag
Asp 633-expression tag
Val 634-expression tag
Arg 635-expression tag
Leu 636-expression tag
Pro 637-expression tag
Asp 638-expression tag
Ala 639-expression tag
His 640-expression tag
Glu 641-expression tag
Val 642-expression tag
Asp 643-expression tag
His 644-expression tag
Arg 645-expression tag
Ile 646-expression tag
Glu 647-expression tag
Ile 648-expression tag
Leu 649-expression tag
Ser 650-expression tag
His 651-expression tag
Asp 652-expression tag
Lys 653-expression tag
Asp 654-expression tag
Tyr 655-expression tag
Asn 656-expression tag
Lys 657-expression tag
Val 658-expression tag
Arg 659-expression tag
Leu 660-expression tag
Tyr 661-expression tag
Glu 662-expression tag
His 663-expression tag
Ala 664-expression tag
Glu 665-expression tag
Ala 666-expression tag
Arg 667-expression tag
Tyr 668-expression tag
Ser 669-expression tag
Gly 670-expression tag
Gly 671-expression tag
Gly 672-expression tag
Ser 673-expression tag
Gly 674-expression tag
Gly 675-expression tag
Gly 676-expression tag
Lys 677-expression tag
Leu 678-expression tag
Glu 679-expression tag
Phe 680-expression tag
Ser 681-expression tag
Ala 682-expression tag
Trp 683-expression tag
Ser 684-expression tag
His 685-expression tag
Pro 686-expression tag
Gln 687-expression tag
Phe 688-expression tag
Glu 689-expression tag
Lys 690-expression tag
Gly 691-expression tag
Gly 692-expression tag
Gly 693-expression tag
Ser 694-expression tag
Gly 695-expression tag
Gly 696-expression tag
Gly 697-expression tag
Ser 698-expression tag
Gly 699-expression tag
Gly 700-expression tag
Ser 701-expression tag
Ala 702-expression tag
Trp 703-expression tag
Ser 704-expression tag
His 705-expression tag
Pro 706-expression tag
Gln 707-expression tag
Phe 708-expression tag
Glu 709-expression tag
Lys 710-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight435753.3
BranchedNumber of molecules1
Total formula weight424.4
Non-Polymers*Number of molecules27
Total formula weight14827.8
All*Total formula weight451005.5
*Water molecules are not included.

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PDB entries from 2026-04-01

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