7WLD

Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0003923	molecular_function	GPI-anchor transamidase activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006091	biological_process	generation of precursor metabolites and energy
G	0006506	biological_process	GPI anchor biosynthetic process
G	0006621	biological_process	protein retention in ER lumen
G	0008218	biological_process	bioluminescence
G	0015631	molecular_function	tubulin binding
G	0016020	cellular_component	membrane
G	0016255	biological_process	attachment of GPI anchor to protein
G	0034235	molecular_function	GPI anchor binding
G	0042765	cellular_component	GPI-anchor transamidase complex
G	0065003	biological_process	protein-containing complex assembly
K	0003923	molecular_function	GPI-anchor transamidase activity
K	0006508	biological_process	proteolysis
K	0008218	biological_process	bioluminescence
K	0008233	molecular_function	peptidase activity
K	0016255	biological_process	attachment of GPI anchor to protein
K	0042765	cellular_component	GPI-anchor transamidase complex
S	0005515	molecular_function	protein binding
S	0005783	cellular_component	endoplasmic reticulum
S	0005789	cellular_component	endoplasmic reticulum membrane
S	0006091	biological_process	generation of precursor metabolites and energy
S	0006506	biological_process	GPI anchor biosynthetic process
S	0008218	biological_process	bioluminescence
S	0016020	cellular_component	membrane
S	0016255	biological_process	attachment of GPI anchor to protein
S	0042765	cellular_component	GPI-anchor transamidase complex
T	0006091	biological_process	generation of precursor metabolites and energy
T	0008218	biological_process	bioluminescence
T	0016255	biological_process	attachment of GPI anchor to protein
T	0042765	cellular_component	GPI-anchor transamidase complex
U	0005515	molecular_function	protein binding
U	0005783	cellular_component	endoplasmic reticulum
U	0005789	cellular_component	endoplasmic reticulum membrane
U	0005886	cellular_component	plasma membrane
U	0006091	biological_process	generation of precursor metabolites and energy
U	0006506	biological_process	GPI anchor biosynthetic process
U	0008218	biological_process	bioluminescence
U	0016020	cellular_component	membrane
U	0016255	biological_process	attachment of GPI anchor to protein
U	0034235	molecular_function	GPI anchor binding
U	0042765	cellular_component	GPI-anchor transamidase complex
U	0046425	biological_process	regulation of receptor signaling pathway via JAK-STAT

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
U	THR66-ILE86
U	LEU166-LEU186
U	LEU188-LEU208
U	LEU237-VAL257
U	GLY259-ALA279
U	SER286-ILE306
U	ILE313-GLY333
U	ILE355-LEU375
U	PHE386-PHE406

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site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
T	VAL528-THR548
S	ILE521-PHE541
G	VAL428-GLY448
G	ALA459-PRO479
G	MET496-THR516
G	TYR544-TRP564
G	PHE600-TRP620

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site_id	SWS_FT_FI3
Number of Residues	29
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
T	ARG549-LEU578
G	GLN449-VAL458
G	ASN517-LEU543
G	LYS621

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
T	ASN164
S	ASN370

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
T	ASN291
T	ASN327

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