7WKD

TRH-TRHR G protein complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Gq	polymer	361	41724.4	1	Pfam (PF00503) UniProt (by SIFTS) (P63092) UniProt (by SIFTS) (P63096) In PDB	Homo sapiens (human)
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	351	38744.4	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (human)	Transducin beta chain 1
3	E	scFV16	polymer	247	26277.3	1		Homo sapiens (Human)
4	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (human)	G gamma-I
5	R	Thyrotropin-releasing hormone receptor	polymer	398	45119.7	1	UniProt (P34981) Pfam (PF00001) In PDB	Homo sapiens (human)	TRH-R,Thyroliberin receptor
6	C	TRH	polymer	3	363.4	1		synthetic construct

Sequence modifications

B: 7 - 345 (UniProt: P62873)

PDB	External Database	Details
Met -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Leu 4	-	expression tag
Leu 5	-	expression tag
Gln 6	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	160090.3
All*	Total formula weight	160090.3

*Water molecules are not included.