7WJQ

Crystal structure of GSDMB in complex with Ipah7.8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Probable E3 ubiquitin-protein ligase ipaH7.8	polymer	242	27895.4	1	UniProt (P18014) Pfam (PF12468) In PDB	Shigella flexneri	Probable RING-type E3 ubiquitin transferase ipaH7.8
2	B	Isoform 2 of Gasdermin-B	polymer	389	44482.6	1	UniProt (Q8TAX9) Pfam (PF04598) Pfam (PF17708) In PDB	Homo sapiens (human)	Gasdermin-like protein
3		water	water		18.0	21	Chemie (HOH)

Sequence modifications

A: 23 - 264 (UniProt: P18014)

PDB	External Database	Details
Asp 262	Met 262	engineered mutation

B: 1 - 406 (UniProt: Q8TAX9)

PDB	External Database	Details
Ser 238	Arg 221	engineered mutation
Ala 239	Lys 222	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72378.0
All*	Total formula weight	72378.0

*Water molecules are not included.