7WJ5
Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | E | Gai1 antibody (scfv16) | polymer | 266 | 28636.8 | 1 | Homo sapiens | ||
5 | R | Soluble cytochrome b562,Somatostatin receptor type 2 | polymer | 518 | 58163.5 | 1 | UniProt (P0ABE7) UniProt (P30874) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,SS-2-R,SS2-R,SS2R,SRIF-1 |
6 | S | Somatostatin-14 (SST-14) | polymer | 14 | 1641.9 | 1 | Pfam (PF03002) UniProt (by SIFTS) (P61278) In PDB BIRD (PRD_001216) | Homo sapiens |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -105 - -1 (UniProt: P0ABE7)
R: 1 - 369 (UniProt: P30874)
PDB | External Database | Details |
---|---|---|
Met -17 | - | initiating methionine |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -148 | - | initiating methionine |
Lys -147 | - | expression tag |
Thr -146 | - | expression tag |
Ile -145 | - | expression tag |
Ile -144 | - | expression tag |
Ala -143 | - | expression tag |
Leu -142 | - | expression tag |
Ser -141 | - | expression tag |
Tyr -140 | - | expression tag |
Ile -139 | - | expression tag |
Phe -138 | - | expression tag |
Cys -137 | - | expression tag |
Leu -136 | - | expression tag |
Val -135 | - | expression tag |
Phe -134 | - | expression tag |
Ala -133 | - | expression tag |
Asp -132 | - | expression tag |
Tyr -131 | - | expression tag |
Lys -130 | - | expression tag |
Asp -129 | - | expression tag |
Asp -128 | - | expression tag |
Asp -127 | - | expression tag |
Asp -126 | - | expression tag |
Lys -125 | - | expression tag |
His -124 | - | expression tag |
His -123 | - | expression tag |
His -122 | - | expression tag |
His -121 | - | expression tag |
His -120 | - | expression tag |
His -119 | - | expression tag |
His -118 | - | expression tag |
His -117 | - | expression tag |
Leu -116 | - | expression tag |
Glu -115 | - | expression tag |
Val -114 | - | expression tag |
Leu -113 | - | expression tag |
Phe -112 | - | expression tag |
Gln -111 | - | expression tag |
Gly -110 | - | expression tag |
Pro -109 | - | expression tag |
Gly -108 | - | expression tag |
Ala -107 | - | expression tag |
Pro -106 | - | expression tag |
Trp -99 | Met 29 | conflict |
Ile -4 | His 124 | conflict |
Leu 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 176136.4 | |
All* | Total formula weight | 176136.4 |