7WI8

Cryo-EM structure of inactive mGlu3 bound to LY341495

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Metabotropic glutamate receptor 3	polymer	887	100021.7	2	UniProt (Q14832) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003)	Homo sapiens (human)	mGluR3
2	C, E (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
3	D, F (A, B)	2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine	non-polymer		353.4	2	Chemie (Z99)

Sequence modifications

A, B: 23 - 879 (UniProt: Q14832)

PDB	External Database	Details
Met -7	-	initiating methionine
Lys -6	-	expression tag
Thr -5	-	expression tag
Ile -4	-	expression tag
Ile -3	-	expression tag
Ala -2	-	expression tag
Leu -1	-	expression tag
Ser 0	-	expression tag
Tyr 1	-	expression tag
Ile 2	-	expression tag
Phe 3	-	expression tag
Cys 4	-	expression tag
Leu 5	-	expression tag
Val 6	-	expression tag
Phe 7	-	expression tag
Ala 8	-	expression tag
Asp 9	-	expression tag
Tyr 10	-	expression tag
Lys 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Asp 15	-	expression tag
Glu 16	-	expression tag
Asn 17	-	expression tag
Leu 18	-	expression tag
Tyr 19	-	expression tag
Phe 20	-	expression tag
Gln 21	-	expression tag
Gly 22	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	200043.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1149.2
All*	Total formula weight	201192.5

*Water molecules are not included.