7WI8

Cryo-EM structure of inactive mGlu3 bound to LY341495

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001641	molecular_function	group II metabotropic glutamate receptor activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005246	molecular_function	calcium channel regulator activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007194	biological_process	negative regulation of adenylate cyclase activity
A	0007196	biological_process	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
A	0007216	biological_process	G protein-coupled glutamate receptor signaling pathway
A	0007268	biological_process	chemical synaptic transmission
A	0008066	molecular_function	glutamate receptor activity
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0030424	cellular_component	axon
A	0042734	cellular_component	presynaptic membrane
A	0043005	cellular_component	neuron projection
A	0043197	cellular_component	dendritic spine
A	0045211	cellular_component	postsynaptic membrane
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0051966	biological_process	regulation of synaptic transmission, glutamatergic
A	0097110	molecular_function	scaffold protein binding
A	0097449	cellular_component	astrocyte projection
A	0098978	cellular_component	glutamatergic synapse
A	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
B	0001641	molecular_function	group II metabotropic glutamate receptor activity
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005246	molecular_function	calcium channel regulator activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007194	biological_process	negative regulation of adenylate cyclase activity
B	0007196	biological_process	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
B	0007216	biological_process	G protein-coupled glutamate receptor signaling pathway
B	0007268	biological_process	chemical synaptic transmission
B	0008066	molecular_function	glutamate receptor activity
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0030424	cellular_component	axon
B	0042734	cellular_component	presynaptic membrane
B	0043005	cellular_component	neuron projection
B	0043197	cellular_component	dendritic spine
B	0045211	cellular_component	postsynaptic membrane
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0051966	biological_process	regulation of synaptic transmission, glutamatergic
B	0097110	molecular_function	scaffold protein binding
B	0097449	cellular_component	astrocyte projection
B	0098978	cellular_component	glutamatergic synapse
B	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission

Functional Information from PROSITE/UniProt

site_id	PS00979
Number of Residues	19
Details	G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS

Chain	Residue	Details
A	VAL157-SER175

---

site_id	PS00980
Number of Residues	23
Details	G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWiCipCepyeYla...DefTCmdC

Chain	Residue	Details
A	CYS527-CYS549

---

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM

Chain	Residue	Details
A	PHE765-MET775

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	86
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---