7WCT
Crystal structure of FGFR4 kinase domain with 7v
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 4 | polymer | 311 | 34695.1 | 1 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (human) | FGFR-4 |
| 2 | B (A) | ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | non-polymer | 656.6 | 1 | Chemie (90F) | |||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | G (A) | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | expression tag |
| Pro 444 | - | expression tag |
| Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34695.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1036.9 | |
| All* | Total formula weight | 35731.9 |
