7WBP

Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron variant spike glycoprotein in complex with its receptor human ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Angiotensin-converting enzyme 2	polymer	596	69038.6	1	UniProt (Q9BYF1) Pfam (PF01401)	Homo sapiens (human)	ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog
2	B (B)	Spike protein S1	polymer	223	25415.9	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
3	C (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D, E, F, H, I (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
5	G (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

B: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Asp 339	Gly 339	engineered mutation
Leu 371	Ser 371	engineered mutation
Pro 373	Ser 373	engineered mutation
Phe 375	Ser 375	engineered mutation
Asn 417	Lys 417	engineered mutation
Lys 440	Asn 440	engineered mutation
Ser 446	Gly 446	engineered mutation
Asn 477	Ser 477	engineered mutation
Lys 478	Thr 478	engineered mutation
Ala 484	Glu 484	engineered mutation
Arg 493	Gln 493	engineered mutation
Ser 496	Gly 496	engineered mutation
Arg 498	Gln 498	engineered mutation
Tyr 501	Asn 501	engineered mutation
His 505	Tyr 505	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	94454.5
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1171.4
All*	Total formula weight	96050.3

*Water molecules are not included.