7W7F

Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Sodium channel subunit beta-1	polymer	218	24732.1	1	UniProt (Q07699) Pfam (PF07686)	Homo sapiens (human)
2	B (C)	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686)	Homo sapiens (human)
3	C (D)	Sodium channel protein type 3 subunit alpha	polymer	2000	226516.5	1	UniProt (Q9NY46) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512)	Homo sapiens (human)	Sodium channel protein brain III subunit alpha,Sodium channel protein type III subunit alpha,Voltage-gated sodium channel subtype III,Voltage-gated sodium channel subunit alpha Nav1.3
4	D (E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	E (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	F, G, H, I, J (B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	AA, BA, CA, K, M... (D)	[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate	non-polymer		718.0	17	Chemie (6OU)
8	L (D)	2,2-diphenyl-~{N}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide	non-polymer		449.5	1	Chemie (8DE)
9	V (D)	(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en	non-polymer		544.8	1	Chemie (9Z9)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	275604.4
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	24
	Total formula weight	14306.3
All*	Total formula weight	290921.7

*Water molecules are not included.