7W7F
Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431
Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0001518 | cellular_component | voltage-gated sodium channel complex |
B | 0006814 | biological_process | sodium ion transport |
B | 0017080 | molecular_function | sodium channel regulator activity |
C | 0016020 | cellular_component | membrane |
D | 0001518 | cellular_component | voltage-gated sodium channel complex |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005248 | molecular_function | voltage-gated sodium channel activity |
D | 0005261 | molecular_function | monoatomic cation channel activity |
D | 0005272 | molecular_function | sodium channel activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0006814 | biological_process | sodium ion transport |
D | 0016020 | cellular_component | membrane |
D | 0016528 | cellular_component | sarcoplasm |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0034702 | cellular_component | monoatomic ion channel complex |
D | 0035725 | biological_process | sodium ion transmembrane transport |
D | 0048266 | biological_process | behavioral response to pain |
D | 0055085 | biological_process | transmembrane transport |
D | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
D | 0086010 | biological_process | membrane depolarization during action potential |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1096 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
D | MET1-SER128 | |
D | GLY1465-VAL1527 | |
D | LYS1576-ILE1587 | |
D | LYS1636-ALA1654 | |
D | LEU1771-LYS2000 | |
D | ARG176-PRO189 | |
D | PRO231-ASP249 | |
D | VAL422-PRO760 | |
D | ILE811-TRP824 | |
D | TRP865-GLY880 | |
D | LEU984-TRP1207 | |
D | LYS1258-ALA1271 | |
D | PHE1318-SER1334 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | LEU129-LEU147 |
site_id | SWS_FT_FI3 |
Number of Residues | 321 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
D | SER148-THR154 | |
D | ALA1291-GLY1298 | |
D | ASN1355-VAL1403 | |
D | ALA1426-LEU1442 | |
D | GLU1546-LEU1556 | |
D | LEU1606-THR1618 | |
D | GLY1673-THR1694 | |
D | ILE1718-GLY1747 | |
D | SER208-SER213 | |
D | MET270-THR368 | |
D | ARG394-TYR400 | |
D | GLU780-SER790 | |
D | GLU845-GLY846 | |
D | GLY900-ASP928 | |
D | ASP950-ILE962 | |
D | GLU1226-THR1238 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | LYS155-ALA175 | |
C | ARG135 |
site_id | SWS_FT_FI5 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | TRP190-VAL207 | |
B | ASN114 |
site_id | SWS_FT_FI6 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | ALA214-ILE230 |
site_id | SWS_FT_FI7 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | VAL250-PHE269 | |
C | ASN74 |
site_id | SWS_FT_FI8 |
Number of Residues | 87 |
Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | PHE369-LEU393 | |
D | PHE929-TRP949 | |
D | GLY1404-ALA1425 | |
D | PHE1695-PRO1717 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | MET401-ALA421 |
site_id | SWS_FT_FI10 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | PHE761-MET779 |
site_id | SWS_FT_FI11 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | VAL791-LYS810 |
site_id | SWS_FT_FI12 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | ASN825-VAL844 |
site_id | SWS_FT_FI13 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | LEU847-SER864 |
site_id | SWS_FT_FI14 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | ALA881-VAL899 |
site_id | SWS_FT_FI15 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | VAL963-LEU983 |
site_id | SWS_FT_FI16 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | PHE1208-PHE1225 |
site_id | SWS_FT_FI17 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | MET1239-LEU1257 |
site_id | SWS_FT_FI18 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | TRP1272-ASN1290 |
site_id | SWS_FT_FI19 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | ALA1299-ARG1317 |
site_id | SWS_FT_FI20 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | ILE1335-VAL1354 |
site_id | SWS_FT_FI21 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | TYR1443-ILE1464 |
site_id | SWS_FT_FI22 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | PHE1528-VAL1545 |
site_id | SWS_FT_FI23 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | VAL1557-LEU1575 |
site_id | SWS_FT_FI24 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | GLY1588-PHE1605 |
site_id | SWS_FT_FI25 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | LEU1619-ILE1635 |
site_id | SWS_FT_FI26 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | LEU1655-PHE1672 |
site_id | SWS_FT_FI27 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
Chain | Residue | Details |
D | ILE1748-ILE1770 |
site_id | SWS_FT_FI28 |
Number of Residues | 3 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08104 |
Chain | Residue | Details |
D | SER484 | |
D | SER485 | |
D | SER486 |
site_id | SWS_FT_FI29 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q14524 |
Chain | Residue | Details |
D | SER1501 |
site_id | SWS_FT_FI30 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
D | ASN211 | |
D | ASN290 | |
D | ASN296 | |
D | ASN302 | |
D | ASN307 | |
D | ASN339 | |
D | ASN1366 | |
D | ASN1380 |