7W72
Structure of a human glycosylphosphatidylinositol (GPI) transamidase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (U) | Phosphatidylinositol glycan anchor biosynthesis class U protein | polymer | 420 | 48448.4 | 1 | UniProt (Q9H490) Pfam (PF06728) | Homo sapiens (human) | Cell division cycle protein 91-like 1,Protein CDC91-like 1,GPI transamidase component PIG-U |
| 2 | B (S) | GPI transamidase component PIG-S | polymer | 533 | 59097.8 | 1 | UniProt (Q96S52) Pfam (PF10510) | Homo sapiens (human) | Phosphatidylinositol-glycan biosynthesis class S protein |
| 3 | C (T) | GPI transamidase component PIG-T | polymer | 527 | 60397.7 | 1 | UniProt (Q969N2) Pfam (PF04113) | Homo sapiens (human) | Phosphatidylinositol-glycan biosynthesis class T protein |
| 4 | D (K) | GPI-anchor transamidase | polymer | 395 | 45302.6 | 1 | UniProt (Q92643) Pfam (PF01650) | Homo sapiens (human) | GPI transamidase,GPI8 homolog,hGPI8,Phosphatidylinositol-glycan biosynthesis class K protein,PIG-K |
| 5 | E (A) | Glycosylphosphatidylinositol anchor attachment 1 protein | polymer | 621 | 67683.8 | 1 | UniProt (O43292) Pfam (PF04114) | Homo sapiens (human) | GPI anchor attachment protein 1,GAA1 protein homolog,hGAA1 |
| 6 | F (N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | G (U) | [2-[[(2~{R})-2-hexanoyloxy-3-[(~{E})-hex-3-enoxy]propoxy]-oxidanyl-phosphoryl]oxy-3,4,5,6-tetrakis(oxidanyl)phenyl] (2~{E},4~{E})-hepta-2,4-dienoate | non-polymer | 622.6 | 1 | Chemie (8JY) | |||
| 8 | H, I (S, T) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 9 | J (K) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
S: 7 - 539 (UniProt: Q96S52)
T: 27 - 552 (UniProt: Q969N2)
| PDB | External Database | Details |
|---|---|---|
| Ala 80 | Glu 80 | conflict |
| Ala 159 | Met 159 | conflict |
| Ala 482 | Gly 482 | conflict |
| Ala 505 | Pro 505 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 26 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 280930.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1105.1 | |
| All* | Total formula weight | 282622.1 |
