Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7W72

Structure of a human glycosylphosphatidylinositol (GPI) transamidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003923	molecular_function	GPI-anchor transamidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006506	biological_process	GPI anchor biosynthetic process
A	0006621	biological_process	protein retention in ER lumen
A	0016020	cellular_component	membrane
A	0016255	biological_process	attachment of GPI anchor to protein
A	0034235	molecular_function	GPI anchor binding
A	0042765	cellular_component	GPI-anchor transamidase complex
A	0180046	biological_process	GPI anchored protein biosynthesis
K	0003923	molecular_function	GPI-anchor transamidase activity
K	0006508	biological_process	proteolysis
K	0008233	molecular_function	peptidase activity
K	0016255	biological_process	attachment of GPI anchor to protein
K	0042765	cellular_component	GPI-anchor transamidase complex
S	0005515	molecular_function	protein binding
S	0005783	cellular_component	endoplasmic reticulum
S	0005789	cellular_component	endoplasmic reticulum membrane
S	0006506	biological_process	GPI anchor biosynthetic process
S	0016020	cellular_component	membrane
S	0016255	biological_process	attachment of GPI anchor to protein
S	0042765	cellular_component	GPI-anchor transamidase complex
S	0180046	biological_process	GPI anchored protein biosynthesis
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005783	cellular_component	endoplasmic reticulum
T	0005789	cellular_component	endoplasmic reticulum membrane
T	0006506	biological_process	GPI anchor biosynthetic process
T	0016020	cellular_component	membrane
T	0016255	biological_process	attachment of GPI anchor to protein
T	0030182	biological_process	neuron differentiation
T	0031410	cellular_component	cytoplasmic vesicle
T	0034235	molecular_function	GPI anchor binding
T	0042765	cellular_component	GPI-anchor transamidase complex
T	0051402	biological_process	neuron apoptotic process
T	0180046	biological_process	GPI anchored protein biosynthesis
U	0003923	molecular_function	GPI-anchor transamidase activity
U	0005515	molecular_function	protein binding
U	0005783	cellular_component	endoplasmic reticulum
U	0005789	cellular_component	endoplasmic reticulum membrane
U	0005886	cellular_component	plasma membrane
U	0006506	biological_process	GPI anchor biosynthetic process
U	0016020	cellular_component	membrane
U	0016255	biological_process	attachment of GPI anchor to protein
U	0034235	molecular_function	GPI anchor binding
U	0042765	cellular_component	GPI-anchor transamidase complex
U	0046425	biological_process	regulation of receptor signaling pathway via JAK-STAT
U	0180046	biological_process	GPI anchored protein biosynthesis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	79
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	229
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W72","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	479
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	225
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	477
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7W72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	5
Details	Region: {"description":"Autoinhibitory loop","evidences":[{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"10793132","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Active site: {"description":"Nucleophile; acyl-thioester intermediate","evidences":[{"source":"PubMed","id":"10793132","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35551457","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W72","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7WLD","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"35165458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37684232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IMX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)