7W53
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41724.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens | |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Neuromedin-U-25 | polymer | 26 | 3213.5 | 1 | UniProt (P48645) Pfam (PF02070) In PDB | Homo sapiens (human) | NmU-25 |
4 | E | scFv16 | polymer | 249 | 26553.6 | 1 | Homo sapiens | ||
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
6 | R | Neuromedin-U receptor 1 | polymer | 755 | 83678.5 | 1 | Pfam (PF07361) Pfam (PF00001) UniProt (by SIFTS) (P0ABE7) UniProt (by SIFTS) (Q9HB89) In PDB | Homo sapiens (human) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
C: -15 - 9 (UniProt: P48645)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Gly 2 | - | expression tag |
Ser 3 | - | expression tag |
Leu 4 | - | expression tag |
Leu 5 | - | expression tag |
Gln 6 | - | expression tag |
Gly 346 | - | expression tag |
Ser 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Gly 354 | - | expression tag |
Gly 355 | - | expression tag |
Gly 356 | - | expression tag |
Gly 357 | - | expression tag |
Ser 358 | - | expression tag |
Ser 359 | - | expression tag |
Gly 360 | - | expression tag |
Val 361 | - | expression tag |
Ser 362 | - | expression tag |
Gly 363 | - | expression tag |
Trp 364 | - | expression tag |
Arg 365 | - | expression tag |
Leu 366 | - | expression tag |
Phe 367 | - | expression tag |
Lys 368 | - | expression tag |
Lys 369 | - | expression tag |
Ile 370 | - | expression tag |
Ser 371 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gln 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 203126.9 | |
All* | Total formula weight | 203126.9 |