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7W53

Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0006940biological_processregulation of smooth muscle contraction
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001607molecular_functionneuromedin U receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0005506molecular_functioniron ion binding
R0005886cellular_componentplasma membrane
R0006821biological_processchloride transport
R0006939biological_processsmooth muscle contraction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0008188molecular_functionneuropeptide receptor activity
R0009055molecular_functionelectron transfer activity
R0016020cellular_componentmembrane
R0019722biological_processcalcium-mediated signaling
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0042597cellular_componentperiplasmic space
R0042924molecular_functionneuromedin U binding
R0046872molecular_functionmetal ion binding
R0050850biological_processpositive regulation of calcium-mediated signaling
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVlNVTALSVERYVaV
ChainResidueDetails
RALA147-VAL163

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU75-SER89
BILE162-ILE176
BLEU290-ALA304
BVAL332-GLY346

site_idPS00967
Number of Residues7
DetailsNMU Neuromedin U signature. FLFRPRN
ChainResidueDetails
CPHE3-ASN9

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ASER151
RTYR119-THR138
RARG203-THR235
RASP316-HIS338

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ALEU175

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
ChainResidueDetails
ATHR181
RALA162-VAL181
RARG257-GLN294
RSER360-SER426

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG178

site_idSWS_FT_FI5
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
AGLY40
ASER47
AASP200
AASN259
ASER333

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER319

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: N-palmitoyl glycine => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
AGLY2

site_idSWS_FT_FI8
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21044946
ChainResidueDetails
ACYS3

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS267

site_idSWS_FT_FI10
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN7
RASN27
RASN41

site_idSWS_FT_FI11
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-110
RILE-15

222926

PDB entries from 2024-07-24

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