7W4O
The structure of KATP H175K mutant in pre-open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43606.8 | 4 | UniProt (Q61743) Pfam (PF01007) Pfam (PF17655) | Mus musculus (house mouse) | Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11 |
| 2 | B, D, F, H (B, D, F, H) | ATP-binding cassette sub-family C member 8 isoform X2 | polymer | 1582 | 177295.5 | 4 | UniProt (A0A1U7R319) Pfam (PF00664) Pfam (PF00005) | Mesocricetus auratus (golden hamster) | SUR1 |
| 3 | I, N, S, X (B, D, F, H) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 4 | J, K, O, P, T... (B, D, F, H) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 5 | AA, L, Q, V (H, B, D, F) | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine | non-polymer | 291.8 | 4 | Chemie (E2H) | |||
| 6 | BA, M, R, W (H, B, D, F) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) |
Sequence modifications
A, C, E, G: 1 - 390 (UniProt: Q61743)
| PDB | External Database | Details |
|---|---|---|
| Lys 175 | His 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 883609.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 5099.1 | |
| All* | Total formula weight | 888708.2 |
