7VXX

Zika virus NS2B/NS3 protease bZipro(C143S) in complex with 4-amino benzamidine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Serine protease subunit NS2B	polymer	53	5865.4	2	UniProt (H8XX12) Pfam (PF01002) UniProt (by SIFTS) (Q32ZE1)	Zika virus
2	B, D (B, D)	Serine protease NS3	polymer	184	19924.6	2	UniProt (H8XX12) Pfam (PF00949) UniProt (by SIFTS) (Q32ZE1)	Zika virus
3	E (D)	P-AMINO BENZAMIDINE	non-polymer		136.2	1	Chemie (PBZ)
4	F, G, H, I (A, B, C, D)	water	water		18.0	54	Chemie (HOH)

Sequence modifications

A, C: 45 - 96 (UniProt: H8XX12)

PDB	External Database	Details
Met 44	-	initiating methionine

B, D: 1 - 177 (UniProt: H8XX12)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 143	Cys 1639	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	51579.9
Non-Polymers*	Number of molecules	1
	Total formula weight	136.2
All*	Total formula weight	51716.1

*Water molecules are not included.