7VVH

Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E140G

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Potassium voltage-gated channel subfamily KQT member 1,Potassium voltage-gated channel subfamily KQT member 1	polymer	69	8122.4	1	UniProt (P51787) In PDB	Homo sapiens (Human)	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1,IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1
2	C	Calmodulin-1	polymer	149	16780.5	1	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
3	C	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4		water	water		18.0	6	Chemie (HOH)

Sequence modifications

A: 364 - 397 (UniProt: P51787)
A: 503 - 533 (UniProt: P51787)

PDB	External Database	Details
Ile 534	-	expression tag
Gly 535	-	expression tag
Ser 536	-	expression tag
Gly 537	-	expression tag

C: 0 - 148 (UniProt: P0DP23)

PDB	External Database	Details
Gly 140	Glu 141	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	24902.9
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	24983.1

*Water molecules are not included.