7VSG
Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in PtdSer-occluded E2-Pi state.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phospholipid-transporting ATPase IG | polymer | 1084 | 124403.6 | 1 | UniProt (Q8NB49) Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) | Homo sapiens (Human) | ATPase IQ,ATPase class VI type 11C,P4-ATPase flippase complex alpha subunit ATP11C |
| 2 | B (B) | Cell cycle control protein 50A | polymer | 361 | 40727.5 | 1 | UniProt (Q9NV96) Pfam (PF03381) | Homo sapiens (Human) | |
| 3 | C (D) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | D (A) | O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine | non-polymer | 788.0 | 1 | Chemie (17F) | |||
| 5 | E (A) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) | |||
| 6 | F, G (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A: 10 - 1091 (UniProt: Q8NB49)
| PDB | External Database | Details |
|---|---|---|
| Arg 8 | - | expression tag |
| Phe 9 | - | expression tag |
| Trp 111 | Cys 114 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 165131.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1296.5 | |
| All* | Total formula weight | 167014.2 |
