7VPU
Crystal structure of the ligand-binding domain of L. thermotolerans Upc2 in complex with ergosterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Sterol uptake control protein 2 (Upc2) | polymer | 332 | 37117.3 | 4 | UniProt (C5DKV6) Pfam (PF11951) | Lachancea thermotolerans CBS 6340 | |
| 2 | E, F, G, H (A, B, C, D) | ERGOSTEROL | non-polymer | 396.6 | 4 | Chemie (ERG) PubChem (5996) PubChem (247705) PubChem (439550) PubChem (444679) PubChem (481705) PubChem (638020) PubChem (5317174) PubChem (5319551) PubChem (5351178) PubChem (5351845) PubChem (71122427) PubChem (6428692) PubChem (6432563) PubChem (6433143) PubChem (6436872) PubChem (6452576) PubChem (6713013) PubChem (6713713) PubChem (7067891) PubChem (7067892) PubChem (7067893) PubChem (7067894) PubChem (7094294) PubChem (9843722) PubChem (9908757) PubChem (9930654) PubChem (9940587) PubChem (10982177) PubChem (11014783) PubChem (11269488) PubChem (12304304) PubChem (12304306) PubChem (12304309) PubChem (12304314) PubChem (12304315) PubChem (16394547) PubChem (16403935) PubChem (16405182) PubChem (21139765) PubChem (21775588) PubChem (22298561) PubChem (40469696) PubChem (40469697) PubChem (40469698) PubChem (40469699) PubChem (40826225) PubChem (40826226) PubChem (45044427) PubChem (177562045) PubChem (1742286) PubChem (46936866) PubChem (69473585) PubChem (101703) PubChem (643780) PubChem (53298316) PubChem (5771570) PubChem (6475768) PubChem (122700025) PubChem (124099377) PubChem (124421304) PubChem (10250169) PubChem (57182145) PubChem (57508500) PubChem (12304302) PubChem (142431933) PubChem (58992544) PubChem (163000929) PubChem (163000920) PubChem (163000938) PubChem (164664366) PubChem (59373909) PubChem (171157824) PubChem (59738932) PubChem (60113883) PubChem (66824684) PubChem (69866435) PubChem (70544775) PubChem (71073084) PubChem (86575818) PubChem (90690511) PubChem (90690567) PubChem (91171783) PubChem (91345764) PubChem (91375317) PubChem (91459231) PubChem (102514697) PubChem (117749797) PubChem (121358225) PubChem (123930382) PubChem (124303809) PubChem (124351226) PubChem (124427258) PubChem (124488022) PubChem (124897130) PubChem (124897142) PubChem (124897144) PubChem (124897147) PubChem (124918943) PubChem (124918944) PubChem (124928616) PubChem (124928617) PubChem (125033743) PubChem (125033744) PubChem (125126218) PubChem (125126219) PubChem (126626805) PubChem (126727349) PubChem (126727350) PubChem (129316836) PubChem (129630206) PubChem (131632336) PubChem (134279700) PubChem (142281730) PubChem (145082804) PubChem (146230523) PubChem (154496532) PubChem (161146965) PubChem (162645168) PubChem (163000919) PubChem (163000921) PubChem (163000922) PubChem (163000923) PubChem (163000924) PubChem (163000925) PubChem (163000926) PubChem (163000927) PubChem (163000928) PubChem (163000930) PubChem (163000931) PubChem (163000932) PubChem (163000933) PubChem (163000934) PubChem (163000935) PubChem (163000936) PubChem (163000937) PubChem (163000939) PubChem (163524814) PubChem (171154016) PubChem (175800618) |
Sequence modifications
A, B, C, D: 471 - 788 (UniProt: C5DKV6)
| PDB | External Database | Details |
|---|---|---|
| Met 445 | - | initiating methionine |
| Ser 446 | - | expression tag |
| Tyr 447 | - | expression tag |
| Tyr 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| Asp 455 | - | expression tag |
| Tyr 456 | - | expression tag |
| Asp 457 | - | expression tag |
| Ile 458 | - | expression tag |
| Pro 459 | - | expression tag |
| Thr 460 | - | expression tag |
| Leu 461 | - | expression tag |
| Val 462 | - | expression tag |
| Pro 463 | - | expression tag |
| Arg 464 | - | expression tag |
| Gly 465 | - | expression tag |
| Ser 466 | - | expression tag |
| Ala 467 | - | expression tag |
| Met 468 | - | expression tag |
| Gly 469 | - | expression tag |
| Ser 470 | - | expression tag |
| - | Ser 587 | deletion |
| - | Ser 588 | deletion |
| - | Ser 589 | deletion |
| - | Ala 590 | deletion |
| - | Val 591 | deletion |
| - | Ser 592 | deletion |
| - | Glu 593 | deletion |
| - | Ser 594 | deletion |
| - | Leu 595 | deletion |
| - | Ala 596 | deletion |
| - | Ala 597 | deletion |
| - | Ser 598 | deletion |
| Val 599 | Ser 599 | engineered mutation |
| Asp 600 | Met 600 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 148469.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1586.6 | |
| All* | Total formula weight | 150056.0 |
