7VPH

Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	mRNA export factor	polymer	378	42398.5	4	UniProt (P78406) Pfam (PF00400) In PDB	Homo sapiens (human)	Rae1 protein homolog,mRNA-associated protein mrnp 41
2	B, D, F, H	Isoform 3 of Nuclear pore complex protein Nup98-Nup96	polymer	67	7785.7	4	UniProt (P52948) Pfam (PF21240) In PDB	Homo sapiens (human)
3	I, J, K, X	ORF6 protein	polymer	21	2486.7	4	UniProt (P0DTC6) Pfam (PF12133) In PDB	Severe acute respiratory syndrome coronavirus 2	ORF6,Accessory protein 6,Non-structural protein 6,ns6,Protein X3
4		water	water		18.0	56	Chemie (HOH)

Sequence modifications

A, C, E, G: 1 - 368 (UniProt: P78406)

PDB	External Database	Details
His 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag
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His 378	-	expression tag

B, D, F, H: 158 - 213 (UniProt: P52948)

PDB	External Database	Details
Met 147	-	initiating methionine
His 148	-	expression tag
His 149	-	expression tag
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Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	210683.7
All*	Total formula weight	210683.7

*Water molecules are not included.