7VMS

Structure of recombinant RyR2 mutant K4593A (Ca2+ dataset)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, B, C, D)	Ryanodine receptor 2	polymer	4966	533595.4	4	UniProt (E9Q401) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF13499) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119)	Mus musculus (house mouse)	RYR-2,RyR2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor
2	B, D, F, H (G, H, I, J)	Peptidyl-prolyl cis-trans isomerase FKBP1B	polymer	176	18984.3	4	UniProt (P68106) Pfam (PF00254)	Homo sapiens (human)	FK506-binding protein 1B,FKBP-1B,
3	I, K, M, P (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	J, L, N, O (A, B, C, D)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)

Sequence modifications

A, B, C, D: 1 - 1311 (UniProt: E9Q401)
A, B, C, D: 1312 - 1339 (PDB: 7VMS)
A, B, C, D: 1340 - 1386 (UniProt: E9Q401)
A, B, C, D: 1387 - 1565 (PDB: 7VMS)
A, B, C, D: 1566 - 2507 (UniProt: E9Q401)
A, B, C, D: 2508 - 2711 (PDB: 7VMS)
A, B, C, D: 2712 - 2915 (UniProt: E9Q401)
A, B, C, D: 2916 - 3610 (PDB: 7VMS)
A, B, C, D: 3611 - 4966 (UniProt: E9Q401)

PDB	External Database	Details
Ala 4593	Lys 4593	engineered mutation

G, H, I, J: 2 - 108 (UniProt: P68106)

PDB	External Database	Details
Met -67	-	initiating methionine
Gly -66	-	expression tag
Ser -65	-	expression tag
Ser -64	-	expression tag
His -63	-	expression tag
His -62	-	expression tag
His -61	-	expression tag
His -60	-	expression tag
His -59	-	expression tag
His -58	-	expression tag
Ser -57	-	expression tag
Ser -56	-	expression tag
Gly -55	-	expression tag
Leu -54	-	expression tag
Val -53	-	expression tag
Pro -52	-	expression tag
Arg -51	-	expression tag
Gly -50	-	expression tag
Ser -49	-	expression tag
His -48	-	expression tag
Met -47	-	expression tag
Ala -46	-	expression tag
Ser -45	-	expression tag
Met -44	-	expression tag
Asp -43	-	expression tag
Glu -42	-	expression tag
Lys -41	-	expression tag
Thr -40	-	expression tag
Thr -39	-	expression tag
Gly -38	-	expression tag
Trp -37	-	expression tag
Arg -36	-	expression tag
Gly -35	-	expression tag
Gly -34	-	expression tag
His -33	-	expression tag
Val -32	-	expression tag
Val -31	-	expression tag
Glu -30	-	expression tag
Gly -29	-	expression tag
Leu -28	-	expression tag
Ala -27	-	expression tag
Gly -26	-	expression tag
Glu -25	-	expression tag
Leu -24	-	expression tag
Glu -23	-	expression tag
Gln -22	-	expression tag
Leu -21	-	expression tag
Arg -20	-	expression tag
Ala -19	-	expression tag
Arg -18	-	expression tag
Leu -17	-	expression tag
Glu -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Pro -13	-	expression tag
Gln -12	-	expression tag
Gly -11	-	expression tag
Gln -10	-	expression tag
Arg -9	-	expression tag
Glu -8	-	expression tag
Pro -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag
Thr 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	2210319.0
Non-Polymers*	Number of molecules	8
	Total formula weight	421.9
All*	Total formula weight	2210741.0

*Water molecules are not included.