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7VMS

Structure of recombinant RyR2 mutant K4593A (Ca2+ dataset)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0002027biological_processregulation of heart rate
A0003143biological_processembryonic heart tube morphogenesis
A0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
A0003300biological_processcardiac muscle hypertrophy
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006941biological_processstriated muscle contraction
A0010460biological_processpositive regulation of heart rate
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0014850biological_processresponse to muscle activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0031000biological_processresponse to caffeine
A0032991cellular_componentprotein-containing complex
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034704cellular_componentcalcium channel complex
A0035994biological_processresponse to muscle stretch
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043924molecular_functionsuramin binding
A0048763molecular_functioncalcium-induced calcium release activity
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051649biological_processestablishment of localization in cell
A0051775biological_processresponse to redox state
A0055085biological_processtransmembrane transport
A0055117biological_processregulation of cardiac muscle contraction
A0060048biological_processcardiac muscle contraction
A0060402biological_processcalcium ion transport into cytosol
A0070296biological_processsarcoplasmic reticulum calcium ion transport
A0070588biological_processcalcium ion transmembrane transport
A0071313biological_processcellular response to caffeine
A0071872biological_processcellular response to epinephrine stimulus
A0072599biological_processestablishment of protein localization to endoplasmic reticulum
A0086005biological_processventricular cardiac muscle cell action potential
A0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
A0097050biological_processtype B pancreatic cell apoptotic process
A0097553biological_processcalcium ion transmembrane import into cytosol
A0098735biological_processpositive regulation of the force of heart contraction
A0098904biological_processregulation of AV node cell action potential
A0098907biological_processregulation of SA node cell action potential
A0098910biological_processregulation of atrial cardiac muscle cell action potential
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
B0001666biological_processresponse to hypoxia
B0002027biological_processregulation of heart rate
B0003143biological_processembryonic heart tube morphogenesis
B0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
B0003300biological_processcardiac muscle hypertrophy
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006941biological_processstriated muscle contraction
B0010460biological_processpositive regulation of heart rate
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0014850biological_processresponse to muscle activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0031000biological_processresponse to caffeine
B0032991cellular_componentprotein-containing complex
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034704cellular_componentcalcium channel complex
B0035994biological_processresponse to muscle stretch
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043924molecular_functionsuramin binding
B0048763molecular_functioncalcium-induced calcium release activity
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051284biological_processpositive regulation of sequestering of calcium ion
B0051649biological_processestablishment of localization in cell
B0051775biological_processresponse to redox state
B0055085biological_processtransmembrane transport
B0055117biological_processregulation of cardiac muscle contraction
B0060048biological_processcardiac muscle contraction
B0060402biological_processcalcium ion transport into cytosol
B0070296biological_processsarcoplasmic reticulum calcium ion transport
B0070588biological_processcalcium ion transmembrane transport
B0071313biological_processcellular response to caffeine
B0071872biological_processcellular response to epinephrine stimulus
B0072599biological_processestablishment of protein localization to endoplasmic reticulum
B0086005biological_processventricular cardiac muscle cell action potential
B0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
B0097050biological_processtype B pancreatic cell apoptotic process
B0097553biological_processcalcium ion transmembrane import into cytosol
B0098735biological_processpositive regulation of the force of heart contraction
B0098904biological_processregulation of AV node cell action potential
B0098907biological_processregulation of SA node cell action potential
B0098910biological_processregulation of atrial cardiac muscle cell action potential
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
C0001666biological_processresponse to hypoxia
C0002027biological_processregulation of heart rate
C0003143biological_processembryonic heart tube morphogenesis
C0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
C0003300biological_processcardiac muscle hypertrophy
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006941biological_processstriated muscle contraction
C0010460biological_processpositive regulation of heart rate
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0014850biological_processresponse to muscle activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030017cellular_componentsarcomere
C0030018cellular_componentZ disc
C0031000biological_processresponse to caffeine
C0032991cellular_componentprotein-containing complex
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034704cellular_componentcalcium channel complex
C0035994biological_processresponse to muscle stretch
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043924molecular_functionsuramin binding
C0048763molecular_functioncalcium-induced calcium release activity
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051284biological_processpositive regulation of sequestering of calcium ion
C0051649biological_processestablishment of localization in cell
C0051775biological_processresponse to redox state
C0055085biological_processtransmembrane transport
C0055117biological_processregulation of cardiac muscle contraction
C0060048biological_processcardiac muscle contraction
C0060402biological_processcalcium ion transport into cytosol
C0070296biological_processsarcoplasmic reticulum calcium ion transport
C0070588biological_processcalcium ion transmembrane transport
C0071313biological_processcellular response to caffeine
C0071872biological_processcellular response to epinephrine stimulus
C0072599biological_processestablishment of protein localization to endoplasmic reticulum
C0086005biological_processventricular cardiac muscle cell action potential
C0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
C0097050biological_processtype B pancreatic cell apoptotic process
C0097553biological_processcalcium ion transmembrane import into cytosol
C0098735biological_processpositive regulation of the force of heart contraction
C0098904biological_processregulation of AV node cell action potential
C0098907biological_processregulation of SA node cell action potential
C0098910biological_processregulation of atrial cardiac muscle cell action potential
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
D0001666biological_processresponse to hypoxia
D0002027biological_processregulation of heart rate
D0003143biological_processembryonic heart tube morphogenesis
D0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
D0003300biological_processcardiac muscle hypertrophy
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006941biological_processstriated muscle contraction
D0010460biological_processpositive regulation of heart rate
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0014850biological_processresponse to muscle activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0030017cellular_componentsarcomere
D0030018cellular_componentZ disc
D0031000biological_processresponse to caffeine
D0032991cellular_componentprotein-containing complex
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034704cellular_componentcalcium channel complex
D0035994biological_processresponse to muscle stretch
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043924molecular_functionsuramin binding
D0048763molecular_functioncalcium-induced calcium release activity
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051284biological_processpositive regulation of sequestering of calcium ion
D0051649biological_processestablishment of localization in cell
D0051775biological_processresponse to redox state
D0055085biological_processtransmembrane transport
D0055117biological_processregulation of cardiac muscle contraction
D0060048biological_processcardiac muscle contraction
D0060402biological_processcalcium ion transport into cytosol
D0070296biological_processsarcoplasmic reticulum calcium ion transport
D0070588biological_processcalcium ion transmembrane transport
D0071313biological_processcellular response to caffeine
D0071872biological_processcellular response to epinephrine stimulus
D0072599biological_processestablishment of protein localization to endoplasmic reticulum
D0086005biological_processventricular cardiac muscle cell action potential
D0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
D0097050biological_processtype B pancreatic cell apoptotic process
D0097553biological_processcalcium ion transmembrane import into cytosol
D0098735biological_processpositive regulation of the force of heart contraction
D0098904biological_processregulation of AV node cell action potential
D0098907biological_processregulation of SA node cell action potential
D0098910biological_processregulation of atrial cardiac muscle cell action potential
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005246molecular_functioncalcium channel regulator activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0016853molecular_functionisomerase activity
G0019227biological_processneuronal action potential propagation
G0019722biological_processcalcium-mediated signaling
G0019855molecular_functioncalcium channel inhibitor activity
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0033017cellular_componentsarcoplasmic reticulum membrane
G0034704cellular_componentcalcium channel complex
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0044325molecular_functiontransmembrane transporter binding
G0050849biological_processnegative regulation of calcium-mediated signaling
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051604biological_processprotein maturation
G0051775biological_processresponse to redox state
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005246molecular_functioncalcium channel regulator activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016529cellular_componentsarcoplasmic reticulum
H0016853molecular_functionisomerase activity
H0019227biological_processneuronal action potential propagation
H0019722biological_processcalcium-mediated signaling
H0019855molecular_functioncalcium channel inhibitor activity
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0033017cellular_componentsarcoplasmic reticulum membrane
H0034704cellular_componentcalcium channel complex
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0044325molecular_functiontransmembrane transporter binding
H0050849biological_processnegative regulation of calcium-mediated signaling
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051604biological_processprotein maturation
H0051775biological_processresponse to redox state
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
I0002027biological_processregulation of heart rate
I0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
I0005102molecular_functionsignaling receptor binding
I0005246molecular_functioncalcium channel regulator activity
I0005515molecular_functionprotein binding
I0005528molecular_functionFK506 binding
I0005737cellular_componentcytoplasm
I0006458biological_process'de novo' protein folding
I0006939biological_processsmooth muscle contraction
I0007204biological_processpositive regulation of cytosolic calcium ion concentration
I0009749biological_processresponse to glucose
I0010459biological_processnegative regulation of heart rate
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016529cellular_componentsarcoplasmic reticulum
I0016853molecular_functionisomerase activity
I0019227biological_processneuronal action potential propagation
I0019722biological_processcalcium-mediated signaling
I0019855molecular_functioncalcium channel inhibitor activity
I0030018cellular_componentZ disc
I0030073biological_processinsulin secretion
I0033017cellular_componentsarcoplasmic reticulum membrane
I0034704cellular_componentcalcium channel complex
I0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
I0042026biological_processprotein refolding
I0042098biological_processT cell proliferation
I0044325molecular_functiontransmembrane transporter binding
I0050849biological_processnegative regulation of calcium-mediated signaling
I0051209biological_processrelease of sequestered calcium ion into cytosol
I0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
I0051284biological_processpositive regulation of sequestering of calcium ion
I0051604biological_processprotein maturation
I0051775biological_processresponse to redox state
I0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
J0002027biological_processregulation of heart rate
J0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
J0005102molecular_functionsignaling receptor binding
J0005246molecular_functioncalcium channel regulator activity
J0005515molecular_functionprotein binding
J0005528molecular_functionFK506 binding
J0005737cellular_componentcytoplasm
J0006458biological_process'de novo' protein folding
J0006939biological_processsmooth muscle contraction
J0007204biological_processpositive regulation of cytosolic calcium ion concentration
J0009749biological_processresponse to glucose
J0010459biological_processnegative regulation of heart rate
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016529cellular_componentsarcoplasmic reticulum
J0016853molecular_functionisomerase activity
J0019227biological_processneuronal action potential propagation
J0019722biological_processcalcium-mediated signaling
J0019855molecular_functioncalcium channel inhibitor activity
J0030018cellular_componentZ disc
J0030073biological_processinsulin secretion
J0033017cellular_componentsarcoplasmic reticulum membrane
J0034704cellular_componentcalcium channel complex
J0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
J0042026biological_processprotein refolding
J0042098biological_processT cell proliferation
J0044325molecular_functiontransmembrane transporter binding
J0050849biological_processnegative regulation of calcium-mediated signaling
J0051209biological_processrelease of sequestered calcium ion into cytosol
J0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
J0051284biological_processpositive regulation of sequestering of calcium ion
J0051604biological_processprotein maturation
J0051775biological_processresponse to redox state
J0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues220
DetailsDomain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues180
DetailsDomain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues220
DetailsDomain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues228
DetailsDomain: {"description":"MIR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues228
DetailsDomain: {"description":"MIR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues840
DetailsDomain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues76
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"17693412","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues352
DetailsDomain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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