7VHZ

Crystal structure of EP300 HAT domain in complex with compound 7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone acetyltransferase p300	polymer	454	52405.7	2	UniProt (Q09472) Pfam (PF06001) Pfam (PF23570) Pfam (PF08214)	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300,p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300
2	C, D, E, G, H... (A, B)	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
3	F, J (A, B)	(2R)-N-(2H-indazol-4-yl)-1-[1-(4-methoxyphenyl)cyclopentyl]carbonyl-pyrrolidine-2-carboxamide	non-polymer		432.5	2	Chemie (6TI)
4	K, L (A, B)	water	water		18.0	539	Chemie (HOH)

Sequence modifications

A, B: 1159 - 1519 (UniProt: Q09472)

PDB	External Database	Details
Gly 1157	-	expression tag
Pro 1158	-	expression tag
Phe 1467	Tyr 1467	engineered mutation

A, B: 1581 - 1666 (UniProt: Q09472)

PDB	External Database	Details
Ser 1520	-	linker
Gly 1521	-	linker
Gly 1578	-	linker
Ser 1579	-	linker
Gly 1580	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104811.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1257.5
All*	Total formula weight	106068.9

*Water molecules are not included.