7V7O

Cryo-EM structure of SARS-CoV-2 S-Delta variant (B.1.617.2), one RBD-up conformation 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein	polymer	1281	142047.2	3	UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	S glycoprotein,E2,Peplomer protein
2	AA, BA, CA, D, DA... (a, b, c, D, d...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	35	In PDB GlyTouCan (G42666HT)
3	MA, NA, OA, PA, QA... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	13	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1206 (UniProt: P0DTC2)

PDB	External Database	Details
Arg 19	Thr 19	variant
Asp 142	Gly 142	variant
Gly 156	Glu 156	variant
-	Phe 157	deletion
-	Arg 158	deletion
Arg 450	Leu 452	variant
Lys 476	Thr 478	variant
Gly 612	Asp 614	variant
Arg 679	Pro 681	engineered mutation
Gly 680	Arg 682	engineered mutation
Ser 681	Arg 683	engineered mutation
Ser 683	Arg 685	engineered mutation
Asn 948	Asp 950	variant
Pro 984	Lys 986	engineered mutation
Pro 985	Val 987	engineered mutation
Glu 1207	-	expression tag
Phe 1208	-	expression tag
Gly 1209	-	expression tag
Ser 1210	-	expression tag
Gly 1211	-	expression tag
Gly 1212	-	expression tag
Tyr 1213	-	expression tag
Ile 1214	-	expression tag
Pro 1215	-	expression tag
Glu 1216	-	expression tag
Ala 1217	-	expression tag
Pro 1218	-	expression tag
Arg 1219	-	expression tag
Asp 1220	-	expression tag
Gly 1221	-	expression tag
Gln 1222	-	expression tag
Ala 1223	-	expression tag
Tyr 1224	-	expression tag
Val 1225	-	expression tag
Arg 1226	-	expression tag
Lys 1227	-	expression tag
Asp 1228	-	expression tag
Gly 1229	-	expression tag
Glu 1230	-	expression tag
Trp 1231	-	expression tag
Val 1232	-	expression tag
Leu 1233	-	expression tag
Leu 1234	-	expression tag
Ser 1235	-	expression tag
Thr 1236	-	expression tag
Phe 1237	-	expression tag
Leu 1238	-	expression tag
Lys 1239	-	expression tag
Gly 1240	-	expression tag
Gln 1241	-	expression tag
Asp 1242	-	expression tag
Asn 1243	-	expression tag
Ser 1244	-	expression tag
Ala 1245	-	expression tag
Asp 1246	-	expression tag
Ile 1247	-	expression tag
Gln 1248	-	expression tag
His 1249	-	expression tag
Ser 1250	-	expression tag
Gly 1251	-	expression tag
Arg 1252	-	expression tag
Pro 1253	-	expression tag
Leu 1254	-	expression tag
Glu 1255	-	expression tag
Ser 1256	-	expression tag
Arg 1257	-	expression tag
Gly 1258	-	expression tag
Pro 1259	-	expression tag
Phe 1260	-	expression tag
Glu 1261	-	expression tag
Gln 1262	-	expression tag
Lys 1263	-	expression tag
Leu 1264	-	expression tag
Ile 1265	-	expression tag
Ser 1266	-	expression tag
Glu 1267	-	expression tag
Glu 1268	-	expression tag
Asp 1269	-	expression tag
Leu 1270	-	expression tag
Asn 1271	-	expression tag
Met 1272	-	expression tag
His 1273	-	expression tag
Thr 1274	-	expression tag
Gly 1275	-	expression tag
His 1276	-	expression tag
His 1277	-	expression tag
His 1278	-	expression tag
His 1279	-	expression tag
His 1280	-	expression tag
His 1281	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	426141.6
Branched	Number of molecules	35
	Total formula weight	14854.0
Non-Polymers*	Number of molecules	13
	Total formula weight	2875.7
All*	Total formula weight	443871.3

*Water molecules are not included.