7V6C
Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dicer-2, isoform A | polymer | 1733 | 199309.0 | 1 | UniProt (A1ZAW0) Pfam (PF00270) Pfam (PF00271) Pfam (PF03368) Pfam (PF20931) Pfam (PF02170) Pfam (PF00636) Pfam (PF00035) | Drosophila melanogaster (Fruit fly) | FI15132p1 |
| 2 | B (B) | R2D2 | polymer | 352 | 39920.4 | 1 | UniProt (Q9VLW8) Pfam (PF00035) | Drosophila melanogaster (Fruit fly) | R2D2,R2d2,isoform A,isoform B,isoform C |
| 3 | C (E) | RNA (5'-R(P*UP*GP*AP*GP*G)-3') | polymer | 21 | 6812.0 | 1 | Drosophila melanogaster | ||
| 4 | D (F) | RNA (5'-R(P*CP*CP*UP*CP*UP*CP*U)-3') | polymer | 21 | 6514.9 | 1 | Drosophila melanogaster | ||
| 5 | E (C) | RNA (5'-R(*AP*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*G)-3') | polymer | 22 | 7141.3 | 1 | Drosophila melanogaster | ||
| 6 | F (D) | RNA (5'-R(*CP*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*UP*C)-3') | polymer | 22 | 6820.1 | 1 | Drosophila melanogaster |
Sequence modifications
A: 1 - 1722 (UniProt: A1ZAW0)
B: 1 - 311 (UniProt: Q9VLW8)
| PDB | External Database | Details |
|---|---|---|
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Leu 208 | Met 208 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -40 | - | initiating methionine |
| Asp -39 | - | expression tag |
| Tyr -38 | - | expression tag |
| Lys -37 | - | expression tag |
| Asp -36 | - | expression tag |
| His -35 | - | expression tag |
| Asp -34 | - | expression tag |
| Gly -33 | - | expression tag |
| Asp -32 | - | expression tag |
| Tyr -31 | - | expression tag |
| Lys -30 | - | expression tag |
| Asp -29 | - | expression tag |
| His -28 | - | expression tag |
| Asp -27 | - | expression tag |
| Ile -26 | - | expression tag |
| Asp -25 | - | expression tag |
| Tyr -24 | - | expression tag |
| Lys -23 | - | expression tag |
| Asp -22 | - | expression tag |
| Asp -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Asp -19 | - | expression tag |
| Lys -18 | - | expression tag |
| His -17 | - | expression tag |
| Arg -16 | - | expression tag |
| Tyr -15 | - | expression tag |
| Thr -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Leu -12 | - | expression tag |
| Tyr -11 | - | expression tag |
| Lys -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Ala -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 266517.6 | |
| All* | Total formula weight | 266517.6 |
