7V61

ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Sodium-dependent neutral amino acid transporter B(0)AT1	polymer	654	73289.4	2	UniProt (Q695T7) Pfam (PF00209) In PDB	Homo sapiens (Human)	Solute carrier family 6 member 19,System B(0) neutral amino acid transporter AT1
2	B, D	Angiotensin-converting enzyme 2	polymer	817	93971.3	2	UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF16959) In PDB	Homo sapiens (Human)	ACE-related carboxypeptidase,Angiotensin-converting enzyme homolog,ACEH,Metalloprotease MPROT15
3	H, I	3E8	polymer	451	49967.0	2		Severe acute respiratory syndrome coronavirus 2
4	K, M	3E8	polymer	214	23507.0	2		Severe acute respiratory syndrome coronavirus 2
5	E, F, G, J, L...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	14	In PDB GlyTouCan (G42666HT)
6	B, C, D, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
7	B, D	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, C: 2 - 634 (UniProt: Q695T7)

PDB	External Database	Details
Met -19	-	initiating methionine
Ala -18	-	expression tag
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Pro -7	-	expression tag
Asp -6	-	expression tag
Glu -5	-	expression tag
Val -4	-	expression tag
Asp -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Arg 1	-	expression tag

B, D: -6 - 805 (UniProt: Q9BYF1)

PDB	External Database	Details
Met -11	-	expression tag
Ala -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Trp 10	-	insertion
Ser 11	-	insertion
His 12	-	insertion
Pro 13	-	insertion
Gln 14	-	insertion
Phe 15	-	insertion
Glu 16	-	insertion
Lys 17	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	481469.3
Branched	Number of molecules	14
	Total formula weight	5941.6
Non-Polymers*	Number of molecules	12
	Total formula weight	2342.9
All*	Total formula weight	489753.8

*Water molecules are not included.