7V3D
Complex structure of serine hydroxymethyltransferase from Enterococcus faecium and its inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine hydroxymethyltransferase | polymer | 417 | 45005.0 | 2 | UniProt (A0A133CK16) Pfam (PF00464) UniProt (by SIFTS) (I3U4H4) | Enterococcus faecium (Streptococcus faecium) | SHMT,Serine methylase |
| 2 | C, F (A, B) | (4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile | non-polymer | 400.5 | 2 | Chemie (5M5) | |||
| 3 | D, G (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 4 | E, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 351 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 414 (UniProt: A0A133CK16)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Val 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 90010.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1366.1 | |
| All* | Total formula weight | 91376.2 |
