7UX4
Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase from Thermoanaerobacter pseudoethanolicus reveal the dynamics of ligand exchange and the proton relay network.
Replaces: 7JNSEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Secondary-alcohol dehydrogenase | polymer | 352 | 37652.8 | 1 | UniProt (P14941) Pfam (PF08240) Pfam (PF00107) UniProt (by SIFTS) (B0KBL1) In PDB | Thermoanaerobacter pseudethanolicus | |
| 2 | B, C, D | NADP-dependent isopropanol dehydrogenase | polymer | 352 | 37680.8 | 3 | UniProt (P14941) Pfam (PF08240) Pfam (PF00107) UniProt (by SIFTS) (B0KBL1) In PDB | Thermoanaerobacter pseudethanolicus | |
| 3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | A, B, C, D | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 5 | A, B, C, D | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 6 | A, B, D | (1S,3S)-3-methylcyclohexan-1-ol | non-polymer | 114.2 | 3 | Chemie (NWO) | |||
| 7 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A: 1 - 352 (UniProt: P14941)
B, C, D: 1 - 352 (UniProt: P14941)
| PDB | External Database | Details |
|---|---|---|
| Ala 86 | Ile 86 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 86 | Ile 86 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150695.2 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 3961.5 | |
| All* | Total formula weight | 154656.7 |
