7UX4
Crystallographic snapshots of ternary complexes of thermophilic secondary alcohol dehydrogenase from Thermoanaerobacter pseudoethanolicus reveal the dynamics of ligand exchange and the proton relay network.
Replaces: 7JNSEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | Secondary-alcohol dehydrogenase | polymer | 352 | 37652.8 | 1 | UniProt (P14941) Pfam (PF08240) Pfam (PF00107) UniProt (by SIFTS) (B0KBL1) | Thermoanaerobacter pseudethanolicus | |
2 | B, C, D (B, C, D) | NADP-dependent isopropanol dehydrogenase | polymer | 352 | 37680.8 | 3 | UniProt (P14941) Pfam (PF08240) Pfam (PF00107) UniProt (by SIFTS) (B0KBL1) | Thermoanaerobacter pseudethanolicus | |
3 | E, K, Q, U (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
4 | F, L, R, V (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
5 | G, J, M, P, S... (A, B, C, D) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
6 | H, N, X (A, B, D) | (1S,3S)-3-methylcyclohexan-1-ol | non-polymer | 114.2 | 3 | Chemie (NWO) | |||
7 | I, O (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
8 | AA, BA, CA, Z (B, C, D, A) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A: 1 - 352 (UniProt: P14941)
B, C, D: 1 - 352 (UniProt: P14941)
PDB | External Database | Details |
---|---|---|
Ala 86 | Ile 86 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 86 | Ile 86 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 150695.2 | |
Non-Polymers* | Number of molecules | 21 |
Total formula weight | 3961.5 | |
All* | Total formula weight | 154656.7 |