7UWN

Structure of the IL-17A-IL-17RA-IL-17RC ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D, E (A, B, D, E)	Interleukin-17A	polymer	170	19311.7	4	UniProt (Q16552) Pfam (PF06083)	Homo sapiens (human)	IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8
2	C, F (C, F)	Interleukin-17 receptor A	polymer	319	36888.6	2	UniProt (Q96F46) Pfam (PF16556) Pfam (PF16578)	Homo sapiens (human)	IL-17 receptor A,IL-17RA,CDw217
3	G (G)	Isoform 5 of Interleukin-17 receptor C	polymer	479	53294.3	1	UniProt (Q8NAC3) Pfam (PF15037)	Homo sapiens (human)	IL-17 receptor C,IL-17RC,Interleukin-17 receptor homolog,IL17Rhom,Interleukin-17 receptor-like protein,IL-17RL,ZcytoR14
4	H (H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	I, J, K, L, M... (A, C, F, G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG)

Sequence modifications

A, B, D, E: 24 - 155 (UniProt: Q16552)

PDB	External Database	Details
Gly 156	-	expression tag
Ala 157	-	expression tag
Pro 158	-	expression tag
Gly 159	-	expression tag
Ser 160	-	expression tag
Ala 161	-	expression tag
Leu 162	-	expression tag
Glu 163	-	expression tag
Val 164	-	expression tag
Leu 165	-	expression tag
Phe 166	-	expression tag
Gln 167	-	expression tag
Gly 168	-	expression tag
Pro 169	-	expression tag
Gly 170	-	expression tag
Ala 171	-	expression tag
Ala 172	-	expression tag
Gly 173	-	expression tag
Leu 174	-	expression tag
Asn 175	-	expression tag
Asp 176	-	expression tag
Ile 177	-	expression tag
Phe 178	-	expression tag
Glu 179	-	expression tag
Ala 180	-	expression tag
Gln 181	-	expression tag
Lys 182	-	expression tag
Ile 183	-	expression tag
Glu 184	-	expression tag
Trp 185	-	expression tag
His 186	-	expression tag
Glu 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag

C, F: 33 - 317 (UniProt: Q96F46)

PDB	External Database	Details
Ser 318	-	expression tag
Ala 319	-	expression tag
Ala 320	-	expression tag
Leu 321	-	expression tag
Glu 322	-	expression tag
Val 323	-	expression tag
Leu 324	-	expression tag
Phe 325	-	expression tag
Gln 326	-	expression tag
Gly 327	-	expression tag
Pro 328	-	expression tag
Gly 329	-	expression tag
Ala 330	-	expression tag
Ala 331	-	expression tag
Glu 332	-	expression tag
Asp 333	-	expression tag
Gln 334	-	expression tag
Val 335	-	expression tag
Asp 336	-	expression tag
Pro 337	-	expression tag
Arg 338	-	expression tag
Leu 339	-	expression tag
Ile 340	-	expression tag
Asp 341	-	expression tag
Gly 342	-	expression tag
Lys 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag

G: 21 - 465 (UniProt: Q8NAC3)

PDB	External Database	Details
Leu 111	Ser 111	conflict
Arg 307	Gln 307	conflict
Ala 466	-	expression tag
Ala 467	-	expression tag
Ala 468	-	expression tag
Leu 469	-	expression tag
Glu 470	-	expression tag
Val 471	-	expression tag
Leu 472	-	expression tag
Phe 473	-	expression tag
Gln 474	-	expression tag
Gly 475	-	expression tag
Pro 476	-	expression tag
Gly 477	-	expression tag
Ala 478	-	expression tag
Ala 479	-	expression tag
Glu 480	-	expression tag
Asp 481	-	expression tag
Gln 482	-	expression tag
Val 483	-	expression tag
Asp 484	-	expression tag
Pro 485	-	expression tag
Arg 486	-	expression tag
Leu 487	-	expression tag
Ile 488	-	expression tag
Asp 489	-	expression tag
Gly 490	-	expression tag
Lys 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	204318.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	9
	Total formula weight	1990.9
All*	Total formula weight	206733.5

*Water molecules are not included.