7UWJ

Structure of the homodimeric IL-25-IL-17RB binary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Interleukin-25	polymer	188	21490.2	2	UniProt (Q9H293) Pfam (PF06083)	Homo sapiens (human)	IL-25,Interleukin-17E,IL-17E
2	B, D (C, D)	Interleukin-17 receptor B	polymer	255	28196.1	2	UniProt (Q9NRM6) Pfam (PF16556) Pfam (PF16578)	Homo sapiens (human)	IL-17 receptor B,IL-17RB,Cytokine receptor-like 4,IL-17 receptor homolog 1,IL-17Rh1,IL17Rh1,Interleukin-17B receptor,IL-17B receptor
3	E, F, G, H, I... (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

A, B: 30 - 177 (UniProt: Q9H293)

PDB	External Database	Details
Asp 26	-	expression tag
Ala 27	-	expression tag
Ser 28	-	expression tag
Ala 29	-	expression tag
Ala 178	-	expression tag
Pro 179	-	expression tag
Ala 180	-	expression tag
Ala 181	-	expression tag
Leu 182	-	expression tag
Glu 183	-	expression tag
Val 184	-	expression tag
Leu 185	-	expression tag
Phe 186	-	expression tag
Gln 187	-	expression tag
Gly 188	-	expression tag
Pro 189	-	expression tag
Gly 190	-	expression tag
Ala 191	-	expression tag
Ala 192	-	expression tag
Gly 193	-	expression tag
Leu 194	-	expression tag
Asn 195	-	expression tag
Asp 196	-	expression tag
Ile 197	-	expression tag
Phe 198	-	expression tag
Glu 199	-	expression tag
Ala 200	-	expression tag
Gln 201	-	expression tag
Lys 202	-	expression tag
Ile 203	-	expression tag
Glu 204	-	expression tag
Trp 205	-	expression tag
His 206	-	expression tag
Glu 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	99372.6
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	100699.9

*Water molecules are not included.