7URU
Crystal structure of the low affinity Fc gamma receptor IIIA variant in complex with the Fc of IgG1.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin gamma-1 heavy chain | polymer | 223 | 25097.4 | 2 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (human) | Immunoglobulin gamma-1 heavy chain NIE |
| 2 | C (C) | Low affinity immunoglobulin gamma Fc region receptor III-A | polymer | 177 | 20262.6 | 1 | UniProt (P08637) Pfam (PF13895) | Homo sapiens (human) | IgG Fc receptor III-A,CD16-II,CD16a antigen,Fc-gamma RIII-alpha,Fc-gamma RIII,Fc-gamma RIIIa,FcRIII,FcRIIIa,FcgammaRIIIA,FcR-10,IgG Fc receptor III-2 |
| 3 | D, E (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 2 | In PDB GlyTouCan (G80858MF) | |||
| 4 | F, G (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | H, I, J (A, B, C) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
C: 1 - 175 (UniProt: P08637)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 38 | Asn 56 | conflict |
| Gln 74 | Asn 92 | conflict |
| Gln 169 | Asn 187 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70457.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2926.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 73826.6 |
