7UQX
Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with UDP-GlcNAc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Exostosin-1 | polymer | 720 | 83404.0 | 1 | UniProt (Q16394) Pfam (PF03016) Pfam (PF09258) | Homo sapiens (human) | Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 1,Putative tumor suppressor protein EXT1 |
| 2 | B (B) | Exostosin-2 | polymer | 674 | 77238.0 | 1 | UniProt (Q93063) Pfam (PF03016) Pfam (PF09258) | Homo sapiens (human) | Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Multiple exostoses protein 2,Putative tumor suppressor protein EXT2 |
| 3 | C (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D, F (A, B) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 2 | Chemie (UDP) | |||
| 5 | E (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | G (B) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) |
Sequence modifications
A: 28 - 746 (UniProt: Q16394)
B: 46 - 718 (UniProt: Q93063)
| PDB | External Database | Details |
|---|---|---|
| Gly 27 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 45 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 160642.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1084.5 | |
| All* | Total formula weight | 162313.1 |
