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7UQX

Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with UDP-GlcNAc

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000271biological_processpolysaccharide biosynthetic process
A0000902biological_processcell morphogenesis
A0001503biological_processossification
A0001958biological_processendochondral ossification
A0001974biological_processblood vessel remodeling
A0002062biological_processchondrocyte differentiation
A0002067biological_processglandular epithelial cell differentiation
A0002244biological_processhematopoietic progenitor cell differentiation
A0002524biological_processhypersensitivity
A0003128biological_processheart field specification
A0003415biological_processchondrocyte hypertrophy
A0003416biological_processendochondral bone growth
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0006024biological_processglycosaminoglycan biosynthetic process
A0006486biological_processprotein glycosylation
A0007033biological_processvacuole organization
A0007155biological_processcell adhesion
A0007166biological_processcell surface receptor signaling pathway
A0007224biological_processsmoothened signaling pathway
A0007369biological_processgastrulation
A0007411biological_processaxon guidance
A0007420biological_processbrain development
A0007492biological_processendoderm development
A0007498biological_processmesoderm development
A0008217biological_processregulation of blood pressure
A0008283biological_processcell population proliferation
A0008375molecular_functionacetylglucosaminyltransferase activity
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009615biological_processresponse to virus
A0009642biological_processresponse to light intensity
A0010467biological_processgene expression
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0014033biological_processneural crest cell differentiation
A0015012biological_processheparan sulfate proteoglycan biosynthetic process
A0015014biological_processheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
A0015020molecular_functionglucuronosyltransferase activity
A0016020cellular_componentmembrane
A0016757molecular_functionglycosyltransferase activity
A0017145biological_processstem cell division
A0019882biological_processantigen processing and presentation
A0021554biological_processoptic nerve development
A0021772biological_processolfactory bulb development
A0022405biological_processhair cycle process
A0030163biological_processprotein catabolic process
A0030166biological_processproteoglycan biosynthetic process
A0030199biological_processcollagen fibril organization
A0030202biological_processheparin metabolic process
A0030204biological_processchondroitin sulfate metabolic process
A0030210biological_processheparin biosynthetic process
A0030509biological_processBMP signaling pathway
A0031069biological_processhair follicle morphogenesis
A0031175biological_processneuron projection development
A0032836biological_processglomerular basement membrane development
A0033627biological_processcell adhesion mediated by integrin
A0035176biological_processsocial behavior
A0035249biological_processsynaptic transmission, glutamatergic
A0035264biological_processmulticellular organism growth
A0035988biological_processchondrocyte proliferation
A0036022biological_processlimb joint morphogenesis
A0036336biological_processdendritic cell migration
A0036339biological_processlymphocyte adhesion to endothelial cell of high endothelial venule
A0042044biological_processfluid transport
A0042060biological_processwound healing
A0042311biological_processvasodilation
A0042328molecular_functionheparan sulfate N-acetylglucosaminyltransferase activity
A0042596biological_processfear response
A0042803molecular_functionprotein homodimerization activity
A0043931biological_processossification involved in bone maturation
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045165biological_processcell fate commitment
A0045202cellular_componentsynapse
A0045453biological_processbone resorption
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0048598biological_processembryonic morphogenesis
A0048733biological_processsebaceous gland development
A0050508molecular_functionglucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
A0050509molecular_functionN-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
A0050891biological_processmulticellular organismal-level water homeostasis
A0050901biological_processleukocyte tethering or rolling
A0051923biological_processsulfation
A0055078biological_processsodium ion homeostasis
A0060047biological_processheart contraction
A0060070biological_processcanonical Wnt signaling pathway
A0060218biological_processhematopoietic stem cell differentiation
A0060349biological_processbone morphogenesis
A0060350biological_processendochondral bone morphogenesis
A0060351biological_processcartilage development involved in endochondral bone morphogenesis
A0060429biological_processepithelium development
A0060441biological_processepithelial tube branching involved in lung morphogenesis
A0060485biological_processmesenchyme development
A0060506biological_processsmoothened signaling pathway involved in lung development
A0060560biological_processdevelopmental growth involved in morphogenesis
A0060792biological_processsweat gland development
A0061484biological_processhematopoietic stem cell homeostasis
A0061744biological_processmotor behavior
A0061974biological_processperichondral bone morphogenesis
A0062094biological_processstomach development
A0065003biological_processprotein-containing complex assembly
A0070593biological_processdendrite self-avoidance
A0070848biological_processresponse to growth factor
A0071503biological_processresponse to heparin
A0071625biological_processvocalization behavior
A0071711biological_processbasement membrane organization
A0071773biological_processcellular response to BMP stimulus
A0072112biological_processpodocyte differentiation
A0072498biological_processembryonic skeletal joint development
A0097021biological_processlymphocyte migration into lymphoid organs
A0097241biological_processhematopoietic stem cell migration to bone marrow
A0098586biological_processcellular response to virus
A0098868biological_processbone growth
A0120193biological_processtight junction organization
A1901706biological_processmesenchymal cell differentiation involved in bone development
A1902494cellular_componentcatalytic complex
A1904888biological_processcranial skeletal system development
A1990823biological_processresponse to leukemia inhibitory factor
B0000139cellular_componentGolgi membrane
B0000271biological_processpolysaccharide biosynthetic process
B0001503biological_processossification
B0001707biological_processmesoderm formation
B0002062biological_processchondrocyte differentiation
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0006024biological_processglycosaminoglycan biosynthetic process
B0006486biological_processprotein glycosylation
B0006487biological_processprotein N-linked glycosylation
B0008217biological_processregulation of blood pressure
B0008375molecular_functionacetylglucosaminyltransferase activity
B0010467biological_processgene expression
B0015012biological_processheparan sulfate proteoglycan biosynthetic process
B0015014biological_processheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
B0015020molecular_functionglucuronosyltransferase activity
B0016020cellular_componentmembrane
B0016757molecular_functionglycosyltransferase activity
B0030210biological_processheparin biosynthetic process
B0042044biological_processfluid transport
B0042311biological_processvasodilation
B0042328molecular_functionheparan sulfate N-acetylglucosaminyltransferase activity
B0042803molecular_functionprotein homodimerization activity
B0043541cellular_componentUDP-N-acetylglucosamine transferase complex
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0046872molecular_functionmetal ion binding
B0046982molecular_functionprotein heterodimerization activity
B0050508molecular_functionglucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
B0050509molecular_functionN-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
B0050891biological_processmulticellular organismal-level water homeostasis
B0051923biological_processsulfation
B0055078biological_processsodium ion homeostasis
B0060047biological_processheart contraction
B0060350biological_processendochondral bone morphogenesis
B0070062cellular_componentextracellular exosome
B1902494cellular_componentcatalytic complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues671
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
BPRO47-LEU718

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:36593275, ECO:0007744|PDB:7SCJ, ECO:0007744|PDB:7SCK, ECO:0007744|PDB:7UQX
ChainResidueDetails
BLEU461
ATYR203
AHIS300

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9ES89
ChainResidueDetails
BARG465
BARG673
BASN490
BASN517
BARG522
BASP538
BASP539
BASP540
BGLU627
BASP628

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:36593275, ECO:0007744|PDB:7SCK
ChainResidueDetails
BTYR582
BSER584
BLYS651
BLYS653

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN288
AARG280
AGLU349

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:36402845, ECO:0000269|PubMed:36593275, ECO:0007744|PDB:7SCH, ECO:0007744|PDB:7SCJ, ECO:0007744|PDB:7SCK, ECO:0007744|PDB:7UQX, ECO:0007744|PDB:7UQY, ECO:0007744|PDB:7ZAY
ChainResidueDetails
BASN637

site_idSWS_FT_FI7
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:36402845, ECO:0000269|PubMed:36593275, ECO:0007744|PDB:7SCK, ECO:0007744|PDB:7ZAY
ChainResidueDetails
ATYR324

site_idSWS_FT_FI8
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:36402845, ECO:0000269|PubMed:36593275, ECO:0007744|PDB:7SCK, ECO:0007744|PDB:7UQY, ECO:0007744|PDB:7ZAY
ChainResidueDetails
AARG346

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN89

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:36402845, ECO:0007744|PDB:7ZAY
ChainResidueDetails
AASN330

227344

PDB entries from 2024-11-13

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