7UOE
SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed RNA polymerase | polymer | 932 | 106781.0 | 1 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 | Pol, RdRp, Non-structural protein 12, nsp12 |
| 2 | B, D (B, D) | Non-structural protein 8 | polymer | 198 | 21903.0 | 2 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 | nsp8 |
| 3 | C (C) | Non-structural protein 7 | polymer | 92 | 10250.0 | 1 | UniProt (P0DTD1) Pfam (PF08716) | Severe acute respiratory syndrome coronavirus 2 | nsp7 |
| 4 | E (P) | Product RNA (35-MER) | polymer | 35 | 11155.7 | 1 | synthetic construct | ||
| 5 | F (T) | Template RNA (55-MER) | polymer | 55 | 17597.4 | 1 | synthetic construct | ||
| 6 | G, H (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I, J (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 8 | K (A) | CYTIDINE-5'-TRIPHOSPHATE | non-polymer | 483.2 | 1 | Chemie (CTP) | |||
| 9 | L (P) | 3'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 308.2 | 1 | Chemie (L2B) | |||
| 10 | M, N, O, P, Q... (A, B, C, D, P...) | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
C: 1 - 83 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Val -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Cys -6 | - | expression tag |
| Thr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Val -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 189590.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 970.8 | |
| All* | Total formula weight | 190560.9 |
