7UMV
Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydropyrido[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity protein phosphatase 10 | polymer | 152 | 17450.0 | 1 | UniProt (Q9Y6W6) Pfam (PF00782) In PDB | Homo sapiens (human) | Mitogen-activated protein kinase phosphatase 5,MKP-5 |
2 | A | 1-{[(10aP)-5,6-dihydropyrido[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one | non-polymer | 313.4 | 1 | Chemie (NUU) | |||
3 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
4 | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 320 - 467 (UniProt: Q9Y6W6)
PDB | External Database | Details |
---|---|---|
Gly 316 | - | expression tag |
Ser 317 | - | expression tag |
His 318 | - | expression tag |
Met 319 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 17450.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 372.5 | |
All* | Total formula weight | 17822.4 |