7UMV

Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((5,6-dihydropyrido[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation
A	0017017	molecular_function	MAP kinase tyrosine/serine/threonine phosphatase activity

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCqaGvsRSA

Chain	Residue	Details
A	ILE406-ALA416

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:16806267, ECO:0000305|PubMed:17400920

Chain	Residue	Details
A	CYS408

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