7UJO

Estrogen Receptor Alpha Ligand Binding Domain in Complex with RU39411

Replaces:  6VIG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (B, D, C, A)	Estrogen receptor	polymer	263	30197.2	4	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	E, F, G, H (B, D, C, A)	(9beta,11beta,17beta)-11-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1,3,5(10)-triene-3,17-diol	non-polymer		435.6	4	Chemie (QYM)
3	I (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	J, K, L, M (B, D, C, A)	water	water		18.0	592	Chemie (HOH)

Sequence modifications

B, D, C, A: 306 - 554 (UniProt: P03372)

PDB	External Database	Details
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
Glu 298	-	expression tag
Asn 299	-	expression tag
Leu 300	-	expression tag
Tyr 301	-	expression tag
Gln 302	-	expression tag
Phe 303	-	expression tag
Ser 304	-	expression tag
Met 305	-	expression tag
Ser 381	Cys 381	conflict
Ser 417	Cys 417	conflict
Ser 530	Cys 530	conflict
Ser 536	Leu 536	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	120788.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1766.7
All*	Total formula weight	122555.5

*Water molecules are not included.