7UIS

Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D)

Replaces:  7KL4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Calcium/calmodulin-dependent protein kinase type II subunit alpha	polymer	268	30548.1	1	UniProt (Q9UQM7) Pfam (PF00069)	Homo sapiens (human)	CaMK-II subunit alpha
2	B (B)	Glutamate receptor ionotropic, NMDA 2B	polymer	22	2782.2	1	UniProt (Q13224)	Homo sapiens	GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B,N-methyl-D-aspartate receptor subunit 3,hNR3

Sequence modifications

A: 7 - 274 (UniProt: Q9UQM7)

PDB	External Database	Details
Asn 135	Asp 135	engineered mutation
Lys 223	Gln 223	engineered mutation

B: 1289 - 1310 (UniProt: Q13224)

PDB	External Database	Details
Asp 1303	Ser 1303	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33330.3
All*	Total formula weight	33330.3

*Water molecules are not included.