7UGN
Cryo-EM structure of BG24 inferred germline Fabs with germline CDR3s and 10-1074 Fabs in complex with HIV-1 Env immunogen BG505-SOSIPv4.1-GT1 - Class 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Envelope glycoprotein gp120 | polymer | 451 | 50871.0 | 3 | UniProt (Q2N0S5) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | D, E, F (D, E, F) | Envelope glycoprotein gp41 | polymer | 129 | 14676.7 | 3 | UniProt (Q2N0S5) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | G, H, I (G, H, I) | BG24 inferred germline Fab with germline CDR3s heavy chain | polymer | 125 | 13685.2 | 3 | Homo sapiens | ||
| 4 | J, K, L (J, K, L) | BG24 inferred germline Fab with germline CDR3s light chain | polymer | 106 | 11212.2 | 3 | Homo sapiens | ||
| 5 | M, N, O (M, N, O) | 10-1074 Fab heavy chain | polymer | 133 | 14791.4 | 3 | Homo sapiens | ||
| 6 | P, Q, R (P, Q, R) | 10-1074 Fab light chain | polymer | 107 | 11701.0 | 3 | Homo sapiens | ||
| 7 | AA, BA, DA, EA, GA... (a, b, d, e, g...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 18 | In PDB GlyTouCan (G42666HT) | |||
| 8 | CA, KA, U (c, k, U) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 9 | NA, X (n, X) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G11052OE) | |||
| 10 | FA (f) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 11 | AB, BB, CB, DB, EB... (C, D, E, F, A...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 12 | FB (Q) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) |
Sequence modifications
A, B, C: 32 - 506 (UniProt: Q2N0S5)
D, E, F: 518 - 664 (UniProt: Q2N0S5)
| PDB | External Database | Details |
|---|---|---|
| - | Glu 61 | deletion |
| - | Thr 62 | deletion |
| Lys 64 | Glu 63 | conflict |
| - | Thr 138 | deletion |
| Arg 169 | Lys 160 | conflict |
| His 173 | Tyr 164 | conflict |
| Ala 174 | Ser 165 | conflict |
| Lys 178 | Arg 169 | conflict |
| Ile 181 | Val 172 | conflict |
| Pro 183 | Gln 174 | conflict |
| - | Gly 180 | deletion |
| - | Asn 181 | deletion |
| - | Arg 182 | deletion |
| - | Ser 183 | deletion |
| - | Asn 184 | deletion |
| - | Asn 185 | deletion |
| - | Ser 186 | deletion |
| Thr 189 | Lys 188 | conflict |
| Ser 190 | Glu 189 | conflict |
| Ala 199 | Ser 198 | conflict |
| Asp 276 | Asn 275 | conflict |
| Arg 278 | Thr 277 | conflict |
| Trp 316 | Ala 313 | conflict |
| Asn 332 | Thr 330 | conflict |
| Asp 386 | Asn 384 | conflict |
| - | Ser 395 | deletion |
| - | Asn 396 | deletion |
| - | Thr 397 | deletion |
| - | Ser 398 | deletion |
| - | Val 399 | deletion |
| - | Gln 400 | deletion |
| - | Gly 401 | deletion |
| - | Ser 402 | deletion |
| - | Asn 403 | deletion |
| - | Ser 404 | deletion |
| - | Thr 405 | deletion |
| - | Gly 406 | deletion |
| Asp 462 | Asn 459 | conflict |
| Ser 471 | Gly 468 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| - | Gly 544 | deletion |
| - | Ile 545 | deletion |
| - | Val 546 | deletion |
| - | Gln 547 | deletion |
| - | Gln 548 | deletion |
| - | Gln 549 | deletion |
| - | Ser 550 | deletion |
| - | Asn 551 | deletion |
| - | Leu 552 | deletion |
| - | Leu 553 | deletion |
| - | Arg 554 | deletion |
| - | Ala 555 | deletion |
| - | Ile 556 | deletion |
| - | Glu 557 | deletion |
| - | Ala 558 | deletion |
| - | Gln 559 | deletion |
| - | Gln 560 | deletion |
| - | His 561 | deletion |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 350813.0 | |
| Branched | Number of molecules | 24 |
| Total formula weight | 13914.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3498.3 | |
| All* | Total formula weight | 368226.1 |
