7UED

Crystal structure of full length mesothelin bound with MORAb-009 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	M	Isoform 4 of Mesothelin	polymer	312	35261.2	1	UniProt (Q13421) Pfam (PF06060) In PDB	Homo sapiens (human)	CAK1 antigen,Pre-pro-megakaryocyte-potentiating factor
2	L	MORAb-009 Fab light chain	polymer	212	23140.5	1		Mus musculus (Mouse)
3	H	MORAb-009 Fab heavy chain	polymer	220	23247.0	1		Mus musculus (Mouse)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	L	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	H	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7		water	water		18.0	33	Chemie (HOH)

Sequence modifications

M: 296 - 600 (UniProt: Q13421)

PDB	External Database	Details
Met 295	-	initiating methionine
Val 593	Met 592	conflict
His 601	-	expression tag
His 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag
His 605	-	expression tag
His 606	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	81648.7
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	3
	Total formula weight	284.2
All*	Total formula weight	82357.4

*Water molecules are not included.