7UED
Crystal structure of full length mesothelin bound with MORAb-009 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (M) | Isoform 4 of Mesothelin | polymer | 312 | 35261.2 | 1 | UniProt (Q13421) Pfam (PF06060) | Homo sapiens (human) | CAK1 antigen,Pre-pro-megakaryocyte-potentiating factor |
| 2 | B (L) | MORAb-009 Fab light chain | polymer | 212 | 23140.5 | 1 | Mus musculus (Mouse) | ||
| 3 | C (H) | MORAb-009 Fab heavy chain | polymer | 220 | 23247.0 | 1 | Mus musculus (Mouse) | ||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (L) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G (H) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | H, I, J (M, L, H) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
M: 296 - 600 (UniProt: Q13421)
| PDB | External Database | Details |
|---|---|---|
| Met 295 | - | initiating methionine |
| Val 593 | Met 592 | conflict |
| His 601 | - | expression tag |
| His 602 | - | expression tag |
| His 603 | - | expression tag |
| His 604 | - | expression tag |
| His 605 | - | expression tag |
| His 606 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 81648.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 284.2 | |
| All* | Total formula weight | 82357.4 |
