7UDS
Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D (D, F, H) | 25.10C Fab Heavy Chain | polymer | 226 | 24270.3 | 3 | Homo sapiens | ||
| 2 | C, E, F (L, G, E) | 25.10C Fab Light Chain | polymer | 209 | 22812.4 | 3 | Homo sapiens | ||
| 3 | G, H, I (A, C, B) | Glycoprotein G1 | polymer | 258 | 28987.4 | 3 | UniProt (Q9IMJ0) | Lassa mammarenavirus | |
| 4 | J, K, L (a, c, b) | Glycoprotein G2 | polymer | 206 | 23348.1 | 3 | UniProt (Q9IMJ0) | Lassa mammarenavirus | |
| 5 | M, R, W (I, O, T) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 6 | N, P, Q, S, U... (J, M, N, P, R...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 7 | O, T, Y (K, Q, V) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 8 | AA, BA, CA, DA, EA... (A, C, B, a, c...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) |
Sequence modifications
A, C, B: 1 - 258 (UniProt: Q9IMJ0)
a, c, b: 259 - 418 (UniProt: Q9IMJ0)
| PDB | External Database | Details |
|---|---|---|
| Cys 206 | Lys 206 | engineered mutation |
| Arg 257 | Leu 257 | engineered mutation |
| Arg 258 | Leu 258 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 328 | Glu 328 | engineered mutation |
| Cys 359 | Gly 359 | engineered mutation |
| Leu 419 | - | expression tag |
| Pro 420 | - | expression tag |
| Glu 421 | - | expression tag |
| Thr 422 | - | expression tag |
| Gly 423 | - | expression tag |
| Leu 424 | - | expression tag |
| Val 425 | - | expression tag |
| Asp 426 | - | expression tag |
| Leu 427 | - | expression tag |
| Glu 428 | - | expression tag |
| Val 429 | - | expression tag |
| Asp 430 | - | expression tag |
| Asp 431 | - | expression tag |
| Asp 432 | - | expression tag |
| Asp 433 | - | expression tag |
| Lys 434 | - | expression tag |
| Ala 435 | - | expression tag |
| Gly 436 | - | expression tag |
| Trp 437 | - | expression tag |
| Ser 438 | - | expression tag |
| His 439 | - | expression tag |
| Pro 440 | - | expression tag |
| Gln 441 | - | expression tag |
| Phe 442 | - | expression tag |
| Glu 443 | - | expression tag |
| Lys 444 | - | expression tag |
| Gly 445 | - | expression tag |
| Gly 446 | - | expression tag |
| Gly 447 | - | expression tag |
| Ser 448 | - | expression tag |
| Gly 449 | - | expression tag |
| Gly 450 | - | expression tag |
| Gly 451 | - | expression tag |
| Ser 452 | - | expression tag |
| Gly 453 | - | expression tag |
| Gly 454 | - | expression tag |
| Gly 455 | - | expression tag |
| Ser 456 | - | expression tag |
| Trp 457 | - | expression tag |
| Ser 458 | - | expression tag |
| His 459 | - | expression tag |
| Pro 460 | - | expression tag |
| Gln 461 | - | expression tag |
| Phe 462 | - | expression tag |
| Glu 463 | - | expression tag |
| Lys 464 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 298254.5 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 8373.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2212.1 | |
| All* | Total formula weight | 308840.3 |
