7UAF
Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, A, C, D) | Meprin A subunit alpha | polymer | 587 | 67285.8 | 4 | UniProt (Q16819) Pfam (PF01400) Pfam (PF00629) Pfam (PF22486) | Homo sapiens (human) | Endopeptidase-2,N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha,PABA peptide hydrolase,PPH alpha |
| 2 | E, G, J, L, M... (E, G, J, L, M...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 3 | F, I (F, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 2 | In PDB GlyTouCan (G47362BJ) | |||
| 4 | H, K, O, R (H, K, O, R) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 4 | In PDB GlyTouCan (G32152BH) | |||
| 5 | CA, HA, S, X (C, D, B, A) | N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide | non-polymer | 372.4 | 4 | Chemie (M6X) | |||
| 6 | AA, DA, FA, IA, KA... (A, C, D, B) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 7 | EA, JA, U, Z (C, D, B, A) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 8 | BA, GA, LA, W (A, C, D, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
B, A, C, D: 22 - 600 (UniProt: Q16819)
| PDB | External Database | Details |
|---|---|---|
| Trp 14 | - | expression tag |
| Ser 15 | - | expression tag |
| His 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Gln 18 | - | expression tag |
| Phe 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Lys 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 269143.3 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 7581.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2956.6 | |
| All* | Total formula weight | 279681.0 |
