7U8G
Cryo-EM structure of the core human NADPH oxidase NOX2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EGFP, Cytochrome b-245 heavy chain chimera | polymer | 864 | 97669.8 | 1 | UniProt (A0A6M5E0N3) UniProt (P04839) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) | Homo sapiens (human) | CGD91-phox,Cytochrome b(558) subunit beta,Cytochrome b558 subunit beta,Heme-binding membrane glycoprotein gp91phox,NADPH oxidase 2,Neutrophil cytochrome b 91 kDa polypeptide,Superoxide-generating NADPH oxidase heavy chain subunit,gp91-1,gp91-phox,p22 phagocyte B-cytochrome |
| 2 | B (B) | Cytochrome b-245 light chain | polymer | 195 | 21033.5 | 1 | UniProt (P13498) Pfam (PF05038) | Homo sapiens (human) | Cytochrome b(558) alpha chain,Cytochrome b558 subunit alpha,Neutrophil cytochrome b 22 kDa polypeptide,Superoxide-generating NADPH oxidase light chain subunit,p22 phagocyte B-cytochrome,p22-phox,p22phox |
| 3 | C (D) | 7G5 - heavy chain | polymer | 225 | 23599.4 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 4 | D (E) | 7G5 - light chain | polymer | 217 | 23521.2 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 5 | E, F, L (A, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 3 | Chemie (POV) | |||
| 6 | G, H, I (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | J, K (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) |
Sequence modifications
A: -259 - -21 (UniProt: A0A6M5E0N3)
A: 2 - 570 (UniProt: P04839)
| PDB | External Database | Details |
|---|---|---|
| Met -293 | - | initiating methionine |
| Ser -292 | - | expression tag |
| Ala -291 | - | expression tag |
| Trp -290 | - | expression tag |
| Ser -289 | - | expression tag |
| His -288 | - | expression tag |
| Pro -287 | - | expression tag |
| Gln -286 | - | expression tag |
| Phe -285 | - | expression tag |
| Glu -284 | - | expression tag |
| Lys -283 | - | expression tag |
| Gly -282 | - | expression tag |
| Gly -281 | - | expression tag |
| Gly -280 | - | expression tag |
| Ser -279 | - | expression tag |
| Gly -278 | - | expression tag |
| Gly -277 | - | expression tag |
| Gly -276 | - | expression tag |
| Ser -275 | - | expression tag |
| Gly -274 | - | expression tag |
| Gly -273 | - | expression tag |
| Ser -272 | - | expression tag |
| Ala -271 | - | expression tag |
| Trp -270 | - | expression tag |
| Ser -269 | - | expression tag |
| His -268 | - | expression tag |
| Pro -267 | - | expression tag |
| Gln -266 | - | expression tag |
| Phe -265 | - | expression tag |
| Glu -264 | - | expression tag |
| Lys -263 | - | expression tag |
| Gly -262 | - | expression tag |
| Ser -261 | - | expression tag |
| Gly -260 | - | expression tag |
| Gln -75 | His 185 | conflict |
| Gly -20 | - | linker |
| Ser -19 | - | linker |
| Gly -18 | - | linker |
| Glu -17 | - | linker |
| Asn -16 | - | linker |
| Leu -15 | - | linker |
| Tyr -14 | - | linker |
| Phe -13 | - | linker |
| Gln -12 | - | linker |
| Gly -11 | - | linker |
| Gly -10 | - | linker |
| Ser -9 | - | linker |
| Gly -8 | - | linker |
| Leu -7 | - | linker |
| Val -6 | - | linker |
| Pro -5 | - | linker |
| Arg -4 | - | linker |
| Gly -3 | - | linker |
| Ser -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
| Gly 1 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 165823.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4176.8 | |
| All* | Total formula weight | 170000.6 |
