7U8F

Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Protein cereblon	polymer	405	46465.4	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB	Homo sapiens (human)
2	B, E	DNA damage-binding protein 1	polymer	836	93347.1	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
3	C, F	IKZF2	polymer	28	3216.7	2	UniProt (Q53SU9) Pfam (PF00096) In PDB	Homo sapiens (human)
4	A, C, D, F	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	A, D	(3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione	non-polymer		417.5	2	Chemie (LWK)
6	B, D, E	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
7	E	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
8		water	water		18.0	19	Chemie (HOH)

Sequence modifications

A, D: 40 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Gly 38	-	expression tag
Ser 39	-	expression tag

B, E: 1 - 699 (UniProt: Q16531)
B, E: 706 - 1140 (UniProt: Q16531)

C, F: 137 - 163 (UniProt: Q53SU9)

PDB	External Database	Details
Ser 136	-	expression tag

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.