7U8F

Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0030177	biological_process	positive regulation of Wnt signaling pathway
A	0031333	biological_process	negative regulation of protein-containing complex assembly
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
A	0035641	biological_process	locomotory exploration behavior
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044325	molecular_function	transmembrane transporter binding
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
B	0003676	molecular_function	nucleic acid binding
B	0005634	cellular_component	nucleus
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016020	cellular_component	membrane
D	0016567	biological_process	protein ubiquitination
D	0030177	biological_process	positive regulation of Wnt signaling pathway
D	0031333	biological_process	negative regulation of protein-containing complex assembly
D	0031334	biological_process	positive regulation of protein-containing complex assembly
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
D	0035641	biological_process	locomotory exploration behavior
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
E	0003676	molecular_function	nucleic acid binding
E	0005634	cellular_component	nucleus

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnq..CgasFtqkgnllrHikl..H

Chain	Residue	Details
C	CYS142-HIS162

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
B	SER2
E	SER2
A	HIS378
A	TRP380
A	TRP386
A	CYS391
A	CYS394
D	CYS323
D	CYS326
D	HIS378
D	TRP380
D	TRP386
D	CYS391
D	CYS394

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS1067
E	LYS1067

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0

Chain	Residue	Details
B	THR1125
E	THR1125

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS1121
E	LYS1121

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