7U8F
Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016020 | cellular_component | membrane |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| A | 0031333 | biological_process | negative regulation of protein-containing complex assembly |
| A | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| A | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| A | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
| A | 0035641 | biological_process | locomotory exploration behavior |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0060173 | biological_process | limb development |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005634 | cellular_component | nucleus |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0016020 | cellular_component | membrane |
| D | 0016567 | biological_process | protein ubiquitination |
| D | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| D | 0031333 | biological_process | negative regulation of protein-containing complex assembly |
| D | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| D | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| D | 0034766 | biological_process | negative regulation of monoatomic ion transmembrane transport |
| D | 0035641 | biological_process | locomotory exploration behavior |
| D | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| D | 0044325 | molecular_function | transmembrane transporter binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 0060173 | biological_process | limb development |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0005634 | cellular_component | nucleus |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnq..CgasFtqkgnllrHikl..H |
| Chain | Residue | Details |
| C | CYS142-HIS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 476 |
| Details | Domain: {"description":"Lon N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01123","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 216 |
| Details | Domain: {"description":"CULT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01124","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 686 |
| Details | Region: {"description":"WD repeat beta-propeller A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 668 |
| Details | Region: {"description":"WD repeat beta-propeller C"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 738 |
| Details | Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
