7U50
APE1 bound to a nucleosome core particle with AP-site at SHL-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3.2 | polymer | 135 | 15257.8 | 2 | UniProt (Q71DI3) Pfam (PF00125) | Homo sapiens (human) | H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o |
| 2 | B, F (B, F) | Histone H4 | polymer | 102 | 11263.2 | 2 | UniProt (P62805) Pfam (PF15511) | Homo sapiens (human) | |
| 3 | C, G (C, G) | Histone H2A type 1 | polymer | 129 | 13990.3 | 2 | UniProt (P0C0S8) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | H2A.1,Histone H2A/ptl |
| 4 | D, H (D, H) | Histone H2B type 1-C/E/F/G/I | polymer | 125 | 13806.0 | 2 | UniProt (P62807) Pfam (PF00125) | Homo sapiens (human) | Histone H2B.1 A,Histone H2B.a,H2B/a,Histone H2B.g,H2B/g,Histone H2B.h,H2B/h,Histone H2B.k,H2B/k,Histone H2B.l,H2B/l |
| 5 | I (I) | DNA (144-MER) | polymer | 147 | 45005.7 | 1 | synthetic construct | ||
| 6 | J (J) | DNA (145-MER) | polymer | 147 | 45610.0 | 1 | synthetic construct | ||
| 7 | K (K) | DNA-(apurinic or apyrimidinic site) endonuclease | polymer | 318 | 35606.5 | 1 | UniProt (P27695) Pfam (PF03372) | Homo sapiens (human) | APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1,AP endonuclease 1,APE-1,REF-1,Redox factor-1 |
Sequence modifications
A, E: 1 - 135 (UniProt: Q71DI3)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Cys 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 234857.0 | |
| All* | Total formula weight | 234857.0 |
