7U4R
Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Dual specificity protein phosphatase 10 | polymer | 152 | 17450.0 | 6 | UniProt (Q9Y6W6) Pfam (PF00782) | Homo sapiens (human) | Mitogen-activated protein kinase phosphatase 5,MKP-5 |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one | non-polymer | 360.5 | 6 | Chemie (L8R) |
Sequence modifications
A, B, C, D, E, F: 320 - 467 (UniProt: Q9Y6W6)
| PDB | External Database | Details |
|---|---|---|
| Gly 316 | - | expression tag |
| Ser 317 | - | expression tag |
| His 318 | - | expression tag |
| Met 319 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 104699.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2163.2 | |
| All* | Total formula weight | 106863.0 |
