7U24
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43661.8 | 4 | UniProt (P70673) Pfam (PF01007) Pfam (PF17655) | Rattus norvegicus (Norway rat) | BIR,Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11 |
| 2 | E (E) | ATP-binding cassette sub-family C member 8 | polymer | 1582 | 177333.6 | 1 | UniProt (Q09427) Pfam (PF00664) Pfam (PF00005) | Cricetus cricetus (black-bellied hamster) | SUR1, Sulfonylurea receptor 1 |
| 3 | F, K, O, S, X (A, B, C, D, E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 5 | Chemie (ATP) | |||
| 4 | AA, BA, CA, G, Z (E, A) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 5 | Chemie (PTY) | |||
| 5 | H, L, P, T (A, B, C, D) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 4 | Chemie (POV) | |||
| 6 | DA, I, J, M, N... (E, A, B, C, D) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 9 | Chemie (P5S) | |||
| 7 | W (E) | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide | non-polymer | 494.0 | 1 | Chemie (GBM) | |||
| 8 | Y (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 351980.6 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 17090.3 | |
| All* | Total formula weight | 369070.9 |
