7TZC

A drug and ATP binding site in type 1 ryanodine receptor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	K, D, E, C	Calmodulin-1	polymer	150	16990.7	4	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (human)
2	F, H, J, O	Peptidyl-prolyl cis-trans isomerase FKBP1A	polymer	107	11836.5	4	UniProt (P62943) Pfam (PF00254) In PDB	Oryctolagus cuniculus (rabbit)	PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase
3	A, B, G, I	Ryanodine receptor 1	polymer	5037	565908.6	4	UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) In PDB	Oryctolagus cuniculus (rabbit)	RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor
4	C, I, A, B, K...	CALCIUM ION	non-polymer		40.1	20	Chemie (CA)
5	I, A, B, G	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (ATP)
6	I, A, B, G	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
7	I, A, B, G	CAFFEINE	non-polymer		194.2	4	Chemie (CFF)
8	I, A, B, G	4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid	non-polymer		329.4	4	Chemie (KVR)
9	I, A, B, G	(2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		788.1	8	Chemie (L9R)

Sequence modifications

K, D, E, C: 0 - 148 (UniProt: P0DP23)

PDB	External Database	Details
His -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	2378943.3
Non-Polymers*	Number of molecules	48
	Total formula weight	13520.1
All*	Total formula weight	2392463.4

*Water molecules are not included.